ABSTRACT
<p><b>OBJECTIVE</b>To establish a rat model of low calcium diet related hyperoxaluria and explore its features.</p><p><b>METHODS</b>By means of randomized blocks design, totally 24 SD male rats were divided into low calcium diet group, medium calcium diet group, and high calcium diet group. Each group was sequentially fed on different calcium diets for 3 days. The urinary volume within 24 hours was recorded, the consistency of urinary oxalate by high-efficiency liquid chromatography, and the consistency of urine creatinine by automatic biochemical analyzer. The consistency was corrected to the output of urinary oxalate of rats in 24 hours, and the results were evaluated by repeated measurement of variance analysis and multivariate analysis of variance.</p><p><b>RESULTS</b>The output of urinary oxalate of rats in 24 hours varied with time (F=7.893, P0.05). The output of urinary oxalate of rats in 24 hours varied with group division (F=3.565, P<0.05). The output of urinary oxalate in 24 hours in three groups on the third day was significantly higher than that on the first day (P<0.05).</p><p><b>CONCLUSION</b>By controlling the calcium intake, we successfully established the model of low calcium diet related hyperoxaluria in rat.</p>
Subject(s)
Animals , Male , Rats , Calcium Carbonate , Diet , Disease Models, Animal , Hyperoxaluria , Urine , Rats, Sprague-DawleyABSTRACT
Although there is great technological disparity between the best foreign lithotripters and domestic ones, the clinical efficacy of the latter is quite good. In this article, the characteristics, developing status and clinical applications of domestic lithotripters are introduced.
ABSTRACT
This article reviews the methods, notes and evaluation of the living animal models of the medical shock wave, including directly shocked animal models, surgical implantation of stones into animal kidney models, implantation of tumor cells into animal models and animal bone models. The living animal models play an important role in studying the medical shock wave.
Subject(s)
Animals , Dogs , Rabbits , Rats , Disease Models, Animal , Guinea Pigs , Kidney , Pathology , Kidney Calculi , Pathology , Therapeutics , Lithotripsy , Models, Animal , Neoplasm Transplantation , Neoplasms, Experimental , PathologyABSTRACT
<p><b>OBJECTIVE</b>To evaluate the therapeutic effects of pneumatic lithotripsy on children urethral calculi.</p><p><b>METHODS</b>Twenty-two cases of the male children with urethral calculi were treated with pneumatic lithotripsy under ureteroscopy.</p><p><b>RESULTS</b>All the patients were treated successfully in a single procedure. The time of lithotripsy was (5.5 +/- 2.2) minutes, and no serious complication such as obvious hematuria, infection and urethral stricture occurred.</p><p><b>CONCLUSIONS</b>It is suggested that pneumatic lithotripsy under ureteroscopy is an effective and simple way for the treatment of urethral calculi in children.</p>