ABSTRACT
Obiective: To verify the effects of aminoguanidine on hemodynamics in sepsis.Method:Experiments were conducted in five groups of anesthetized dogs (each group n=8).In group 1,lipopolysaccharide (LPS)was injected intravenously, Group 2 received both LPS and L-arginine (300mg/kg)intravenously. Group 3 received both LPS and N-nitro-Larginine (L-NNA,20mg/kg) intravenously.Group 4 received both LPS and aminoguanidine (30mg/kg) intravenously. Group 5 received only saline. Hemodynamic and oxygenational data were measured or calculated. Extravascular lung water (EVLW)was measured. Result:L-arginine increased CI and decreased PVRI,while treatment with aminoguanidine without significant increased the BP,SVRI and PVRI.But all of untoward hemodynamic effcts of LPS were exacerbated by the addition of L-NNA,as DO_2 was significantly decreased by L-NNA,Therefore,though O_2ER was also increase (insufficiently),VO_2 was still decreased significantly.EVLW was markedly increased by LNNA. Conclusion:The No-selective inhibition with adiministration of aminoguanidine may have considerable value in the therapy of endotoxin shock.
ABSTRACT
Objective To investigate the effects of gelatins and dextran on fibrinogen and platelet glycoproteinⅡb/Ⅲa (GPⅡb/Ⅲa).Methods One hundred and five patients for selective cholecystectomy were randomly divided into four groups. In groupⅠ normal saline 30ml/kg was infused, in groupⅡ dextran-70 30ml/kg,in groupⅢ urea-linked gelatin 30ml/kg and group Ⅳ modified fluid gelatin 30ml/kg. The blood samples were taken before infusion ,two hours and three hours after the infusion, to measure platelet maximum aggregation rate (MAR), levels of Fbg and GPⅡb/Ⅲa,respectively.Results As compared with those in other groups, MAR and level of GPⅡb/Ⅲa decreased significantly in groupⅡ(P