ABSTRACT
Objective To investigate the clinical efficacy of teprenone on aspirin-induced gastric mucosa injury and provide theoretical basis for protective mechanism.Methods A total of 84 patients who needed long time aspirin treatment were enrolled in this study.All the 84 cases were divided into two groups according to the treatment method:aspirin treatment group (group A,42 cases) and teprenone + aspirin treatment group (group B,42 cases).The gastrointestinal symptoms,adverse reactions,and fecal occult blood test and endoscopy score were recorded after treatment of 3 months,6 months and 1 year.Results The incidence of gastrointestinal symptoms [4.76％ (2/42),9.52％ (4/42),21.43％ (9/42),0,2.38％ (1/42),11.90％ (5/42)],fecal occult blood test score [(0.052 + 0.006),(0.183 + 0.014),(0.315 + 0.028) scores and (0.006 + 0.001),(0.037 + 0.008),(0.206 + 0.013) scores] and endoscopy score [(0.072 + 0.011),(0.283 + 0.018),(0.453 ± 0.034) scores and (0.008 + 0.003),(0.046 + 0.010),(0.243 ± 0.016)scores]was significantly increased in group A and group B along with the time of treatment (P ＜ 0.05 or ＜ 0.01).The incidence of gastrointestinal symptoms,fecal occult blood test score and endoscopy score was significantly lower in group B than that in group A after treatment of 3 months,6 months and 1 year (P ＜ 0.05 or ＜ 0.01).The incidence of gastrointestinal adverse reaction was no significant difference between two groups after treatment of 3 months,6 months and 1 year (P ＞ 0.05).Conclusion Teprenone shows effective activity against aspirin-induced gastric damage with a low incidence of adverse reactions,and it is worthy to spread in the clinical application.