ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of cake-separated moxibustion in treatment of hyperlipemia.</p><p><b>METHODS</b>Sixty rabbits were randomly divided into 4 groups, a blank group,a model group, a direct moxibustion group and a cake-separated moxibustion group. Hyperlipemia model was developed by high fat diet of cholesterol. Changes of ultrastructures of endothelial cells of the aorta of the rabbit were observed with electron microscope.</p><p><b>RESULTS</b>The endothelial cells in the cake-separated moxibustion group were more intact, most of them were normal in forms, internal elastic membrane was continuous, their thickness was even, the cells of smooth muscles in the medial membrane were relatively normal, which are similar to those in the blank control group. But the structure of endothelial cells of the aorta in the model group disappeared, in cytoplasm the sedimentation of a great number of lipids can be seen, internal elastic membrane was interrupted, the thickness was uneven, with focal dissolution, the cells of smooth muscle in the medial membrane had sedimentation of lipids, with frothy change.</p><p><b>CONCLUSION</b>Cake-separated moxibustion has a certain protective action on endothelial cells of the aorta in the rabbit of hyperlipemia.</p>