ABSTRACT
Objective: To study ultrasound contrast enhanced mode of benign and malignant thyroid nodule and the change of related quantitative parameter of time intensity curve(TIC).Methods: Retrospective analysis was applied to analyze the mode that contrast agent went into nodules when 125 thyroid nodules of 112 patients with thyroid nodule received ultrasound contrast,and to analyze enhanced mode and distribution situation of contrast agent.The change of TIC was observed and analyzed.And when contrast agent went into nodule,the quantitative parameters included arrive time(AT),peak intensity(PI),time to peak(TTP)and K value of rate of curve were recorded.Results: 58 nodules were benign and 67 nodules were malignant in the 125 thyroid nodules.The rim of benign nodules appeared circular enhancement(82.7％)after contrast agent went into benign nodule.And the malignant nodules appeared non-circular enhancement(77.6％),and the difference of them was no significant(x2=28.32,P＜0.05).Most of malignant nodules appeared asymmetrical enhancement after contrast agent was infused in them(91.0％),and the difference of ultrasound contrast between benign nodules and malignant nodules was significant(x2=17.56,P＜0.05).When the contrast agent of malignant nodules achieved peak value,its main appearance was low enhancement(83.6％),and the contrast agent of benign nodules achieved peak value,the main appearance was equivalent enhancement(86.2％),and the difference of appearance between malignant nodule and benign nodule was significant(x2=41.65,P＜0.05).The differences of parameters of TIC included AT,PI,TTP and K value between malignant nodules and benign nodules were significant(t=2.964,t=3.021,t=-2.914,t=2.652,P＜0.05).Conclusion: For diagnosis of thyroid nodule that mainly contained solid nodule and cystic solid nodule,ultrasound contrast enhancement and TIC included variously quantitative parameters have higher clinical application value.