ABSTRACT
@#AIM:To investigate the effects of laser <i>in situ</i> keratomileusis(LASIK)on ocular surface by femtosecond laser or mechanical microkeratome for creating corneal flap, and to study the effect of different corneal flap method on ocular surface after operation. <p>METHODS: This study included 218 cases(436 eyes)myopia patients from January 2016 to January 2017 in our hospital for refractive surgery, their medical records were retrospectively analyzed. They all underwent LASIK surgery treatment and complained of different degree of dry eye postoperatively, foreign body sensation and discomfort. Mechanical microkeratome was used in 61 cases(122 eyes)of patients and they were as control group, with femtosecond laser, 157 cases(314 eyes)were set as observation group. We compared dry eye symptom scores, corneal fluorescein staining(FL)score, break-up time(BUT)and basic tear secretion test(SⅠt)between the two groups preoperatively and postoperatively 1wk, 1, and 3mo. <p>RESULTS: Before surgery, dry eye symptoms scoring of two groups had no statistically significant difference(<i>P</i>>0.05); the scores of the two groups were significantly different before and after surgery(<i>P</i><0.05); postoperatively 1wk, dry eye symptoms score of control group was greater than that of the observation group with significant difference(<i>P</i><0.05), the sores at 1 and 3mo after surgery were not different between the two groups(<i>P</i>>0.05). There was no significant differenc on the preoperative BUT between the two groups(<i>P</i>>0.05). BUT before and after surgery was significantly different of both groups(<i>P</i><0.05). BUT of control group was significantly lower than that of observation group postoperatively(<i>P</i><0.05). Before surgery, FL score of two groups had no statistically significant difference(<i>P</i>>0.05); the scores of the two groups were significantly different before and after surgery(<i>P</i><0.05); postoperatively 1wk and 1mo, FL score of control group was greater than that of the observation group with significant difference(<i>P</i><0.05), the sores at 3mo after surgery were not different between the two groups(<i>P</i>>0.05). Before surgery, SⅠt of two groups had no statistically significant difference(<i>P</i>>0.05); the scores of the two groups were significantly different before and after surgery(<i>P</i><0.05); postoperatively 1wk and 1mo, SⅠt of control group was lower than that of the observation group with significant difference(<i>P</i><0.05); SⅠt at 3mo after surgery were not different between the two groups(<i>P</i>>0.05). Two groups of patients had no serious postoperative complications occurred.<p>CONCLUSION: Compared with the mechanical microkeratome for creating corneal flap, LASIK with femtosecond laser for creating corneal flap has less effect on ocular surface and has mild symptoms of dry eye, the effect time is also shortened.
ABSTRACT
OBJECTIVE@#To investigate the effect of fructose-1,6-diphosphete(FDP) on myocardial preservation in pulmonary operations.@*METHODS@#One hundred and six patients undergoing selective pulmonary lobectomy or segmentectomy were randomly divided into 2 groups with 53 patients each. FDP 200 mg/kg was infused intravenously before anesthesia in the FDP group, while 5% glucose with the same volume was given instead of FDP in the control group. ECGs were monitored from before the anesthesia to 72 h after the operation;the time and type of arrhythmia were recorded. Blood samples were taken before the operation (T0), immediately after the operation(T1), at 24 h(T2),48 h(T3)and 72 h(T(4)) after the operation to determine plasma creatine kinase isoenzyme MB(CK-MB) and cardiac troponin I(cTnI) concentrations.@*RESULTS@#The incidence of arrhythmia in FDP group (35 times) was significantly lower than that in the control group(67 times). The incidence of all types of arrhythmia in the FDP group was also significantly lower than that in the control group. The concentrations of CK-MB and cTnI in the FDP group were significantly lower than those in the control group at T1, T2, T3, and T4.@*CONCLUSION@#FDP is effective for myocardial preservation in pulmonary operations.