EXPERIMENTAL STUDIES ON THE MECHANISMS OF THE RARITY OF METASTASIS TO SKELETAL MUSCLE / 解放军医学杂志

To investigate the mechanisms of the rarity of metastasis to skeletal muscles. Animal models of blood borne metastasis to skeletal muscle and lung were established,VCAM 1 expressions of the microvascular endothelium in these organs were estimated using immunohistochemistry.The effects of skeletal muscle conditioned media(MCM) on several tumor cell lines were tested by MTT assay.Tumor cells or metastatic foci could be seen rarely in the connective tissue beside muscle bundles of the femoral muscles,however, there is no metastatic foci among muscle cells.The difference of metastatic rate between skeletal muscles and lungs was significant( P