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Objective Through the analysis of the clinicopathological features of triple-negative breast cancer(TNBC),the relationship between recurrence,metastasis,the location of metastatic lymph nodes and primary lesions in breast cancer patients with TNBC was investigated. Methods The clinical data of 763 patients with TNBC from December 2008 to December 2012 in our hospi-tal were retrospectively analyzed. Results The onset average age of TNBC breast cancer was 49 years old,and 84. 7% of patients with early stage. The recurrence and metastasis rates of lymph node-positive patients were significantly higher than those of lymph node-negative patients,and increased the number of lymph nodes(P<0. 001). In the patient with negative for lymph nodes,the pri-mary tumor recurred in the inner quadrant and the metastasis rates were the highest(9. 8% and 13. 7% )(P<0. 05). Univariate anal-ysis showed that lymph node status,surgical procedure,and radiation dose were factors influencing recurrence and metastasis in pa-tients with TNBC(P<0. 05). Multivariate analysis showed that clinical stage and lymph node status were independent risk factors for recurrence of TNBC. Clinical stage and surgical approach were independent risk factors for the metastasis of TNBC ( P <0. 05). Conclusion (1)The proportion of patients with TNBC at early stage is high. The main pathological type is invasive ductal carcino-ma,and the positive expression rate of ki67 is high. (2)The prognosis of patients with positive lymph nodes was related to the number of metastatic lymph nodes,and there was not significant correlated with the location of primary tumor. For patients with negative lymph nodes,the primary tumor was located in the inner quadrant with the highest recurrence and metastasis rates. (3)The recurrence rate of TNBC patients increased with the increase of BMI,but for obese patients,the recurrence rate decreased. (4)Lymph node status,clini-cal stage,surgical procedure,and radiotherapy dose all affect recurrence and metastasis of patients with TNBC. (5)Clinical stage and lymph node status are independent risk factors for the recurrence of TNBC. Clinical stage and surgical approach are independent risk factors for the metastasis of TNBC.
ABSTRACT
The triple negative breast cancer is one of importance in clinical subtypes of breast cancer, which is easy to recur and metastasis, and its prognosis is very poor.Radiotherapy, as an effective method for breast cancer,can reduce the risk of local recurrence.This article elaborates its characteristics,the progress of ra-diotherapy in the breast conserving surgery and modified radical mastectomy in triple negative breast cancer,when is the appropriate time for radiotherapy and radiotherapy sensitization,and hope that it will be helpful to the treat-ments.
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Cancer malnutrition observed in 31%~87% patients with cancer can reduce the tolerance and compliance to radiotherapy ,interrupt or delay the treatment ,and significantly affect the prognosis .The malnu-trition may be aggravated when the duration of radiotherapy is prolonged and chemotherapy is applied concurrent -ly.PG-SGA is the most suitable method for nutritional risk screening in patients with malignant tumor .According to the result of nutrition assessment ,giving the adaptive nutrition support can improve the nutritional status of pa-tients and the curative effect in the early stage of radiotherapy ,as wells as post radiotherapy .
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Objective To explore the therapy effect of candesartan plus CSDP on elderly hypertensive patients with renal dysfunction.Methods Eighty elderly patients with essential hypertension and renal dysfunction were selected as our subjects.All subjects were randomly divided into candesartan group and candesartan + CSDP group,every group for 40 subjects.Patients in candesartan group were treated with 4 mg candesartan once per day for 6 months.Patients in candesartan + CSDP group were given CSDP 10 capsules three times / day beside 4 mg candesartan,once per day for 6 months.The levels of Cr,BUN,Ccr changes were measured.Results Two therapy strategies can decrease blood pressure and the decrease rate of blood pressure in candesartan + CSDP group was higher than that of candesartan group.The level of Cr,BUN in patients with candesartan + CSDP group after treatment performing were (104.6 ± 6.5) μmol/L,(6.21 ± 4.80) mmol/L,lower than that in before treatment (196.8 ± 2.6) μ mol/L,(9.84 ± 3.20) mmol/L.And the Ccr increased from (58.1 ± 4.9)ml/min to (117.2 ± 6.4)ml/min.The differences were significant (t =2.213,2.302,2.136,P ＜ 0.05).However the differences between before and after treatment with only candesartan treat weren't significant (P ＜ 0.05).Conclusion Candesartan + CSDP might show a synergistic effect compared with candesartan in term of curing elderly hypertensive patients with renal dysfunction.
ABSTRACT
@#To improve human cognition of sub-health condition by analyzing current situation of sub-health researches,the authors of this article reviewed the concept of sub-health,etiological factor,epidemiology,diagnostic code and other sides.