ABSTRACT
Objective Brain metastasis of non-small cell lung cancer (NSCLC) significantly reduces the survival time of the patients, and no effective tool is yet available for the prediction of the risk.This study aimed to develop an effective and feasible nomogram for predicting brain metastasis of NSCLC after radical surgery.Methods This retrospective study included 636 cases of NSCLC treated by radical resection of the tumor in our hospitals between January 2010 and January 2014.Based on the analysis of the risk factors for brain metastasis, we developed a nomogram using logistic regression with the R-language, calculated the confidence interval (CI) of the C-index using the bootstrap, and then internally verified the overfitting degree of the model to evaluate its stability.Results Brain metastasis developed in 94 of the 636 patients.According to the results logistic regression analysis, the risk factors for brain metastasis included history of cigarette smoking (OR=1.783, 95% CI: 1.037-3.066), pathological types (OR=0.453, 95% CI: 0.275-0.744), the T stage (OR=2.047, 95% CI: 1.511-2.774), and the N stage (OR=1.588, 95% CI: 1.154-2.184).The nomogram showed a coefficient of coincidence of 0.73 (0.71-0.82) and a mean absolute error rate of 0.012, which indicated an excellent stability.Conclusion The nomogram we developed can be used to predict the risk of brain metastasis in individual NSCLC patients after surgery, contributing to follow-up programs and preventive strategies for brain metastasis.
ABSTRACT
Objective To investigate the effect of bevacizumab combined with chemotherapy on the expression of EGFR and HER in the patients with metastatic colorectal cancer .Methods Sixty patients with metastatic colorectal cancer treated in this hos-pital from January 2013 to October 2016 were selected and randomly divided into the experiment group (bevacizumab combined with FOLFOX-6 chemotherapy regimen) and control group (FOLFOX-6 chemotherapy regimen) 30 cases in each group .The curative effects were observed in the two groups .The levels of serum HER and EGFR were detected by enzyme-linked immunosorbent assay (ELISA) .Results The total effective rate after treatment in the experiment group was 53 .33% ,which in the control group was 33 .33% ,the difference was statistically significant (P< 0 .05) .After treatment ,the levels of serum HER and EGHR in the two groups were decreased to some extent ,moreover the experiment group had more decrease than the control group ,the difference be-tween the two groups was statistically significant (P<0 .05) .The occurrence rate of adverse reactions had no statistical difference between the two groups (P>0 .05) .Conclusion Bevacizumab combined with chemotherapy has good effect in the patients with metastatic colorectal cancer .
ABSTRACT
Objective To investigate the diagnostic value of quantitative analysis of the color change of iodine staining for early esophageal cancer.Methods A total of 58 patients with suspected esophageal diseases were recruited to this study.The lesions were stained with lugols iodine,and biopsies were performed.Quantitative analysis of color change under endoscopy was also performed by analysis software and the results were compared with pathological findings.Results A total of 62 iodine-unstained lesions in 58 patients were found,includiug 19 chronic inflammation,13 low-grade intraepithelial neoplasia,11 high-grade intraepithelial neoplasia and 19 squamous cell cancer.The color parameters of R/R'(red) and H/H'(hue) were significantly different among the four groups (P＜0.05).Conclusion Computerized chromoendoscopy is helpful in determining pathological characteristics of esophageal lesions,thereby improving the accuracy of endoscopic biopsy and the diagnosis rate of early esophageal cancer.