ABSTRACT
Objective To systematically assess the relation between angiotensin-I converting enzyme(ACE) gene insertion/deletion (I/D) variation and type 2 diabetic nephropathy (T2DN) onset risk among Chinese population.Methods The related literatures were retrieved from the China National Knowledge Infrastructure (CNKI) and Wanfang Data until June 1st,2016.The RevMan 5.0 was used to conduct the statistical analysis.The merge OR value and corresponding 95% confidence interval(95%CI) were used to assess ACE gene I/D polymorphism and T2DN onset risk.Results Totally 29 papers with 4 357 subjects were included according to the inclusion and exclusion standard,including 2 208 cases of DN and 2 149 cases of T2DM without DN.Meta analysis showed that compared with ACE gene I/D polymorphism I allele,D allele could significantly increase the risk of T2DM patients suffering from DN,the OR value and corresponding 95%CI were 1.44(1.25,1.66);the gene analysis showed that ACE gene I/D polymorphism loci were significantly correlated with DN onset risk in the Asian population.The corresponding relative onset risk OR and 95%CI were 1.42(1.15,1.76) and 1.75(1.46,2.10) in the dominant and recessive genetic model.The Begg′s test showed that the included data had no obvious publication bias existence.Conclusion ACE gene I/D polymorphism is closely correlated with the onset risk of T2DN,and D allele might be a risk genetic factor for DN occurrence in the patients with T2DM.
ABSTRACT
Objective To evaluate the association between SNP 399 in X‐ray cross‐complementing group 1 (XRCC1) and na‐sopharyngeal carcinoma susceptibility .Methods The case‐control studies on the association between SNP 399 in XRCC1 (X‐ray cross‐complementing group 1) and nasopharyngeal carcinoma susceptibility were collected by CBM disc and Pubmed .Various re‐search and statistical analysis were used by Stata12 .0 and Review Manager 5 .0 software .Taking the fixed effects model or random effects model to merge OR values and corresponding 95% confidence intervals to assess Arg399Gln polymorphism and genetic sus‐ceptibility to nasopharyngeal .Results Compared 399Gln with 399Arg allele ,combined OR and 95% CI were 1 .14 (1 .04 - 1 .26) respectively ,and the results of heterogeneity test was I2 = 32% ,PHet = 0 .18 .Under the recessive and co‐dominant models ,combined OR and 95% CI were 1 .30(1 .04 - 1 .63) and 1 .37(1 .09 - 1 .72) respectively ,and with no significant heterogeneity was observed (I2 = 0 ,PHet = 1 .00) and (I2 = 0 ,PHet = 0 .96) .Conclusion XRCC1 gene Arg399Gln polymorphism is closely related to the genetic susceptibility of NPC ,399Gln allele may be a risk of genetic factors in NPC incidence in asians .