ABSTRACT
Objective To explore the value of the combined detection of four tumor markers of serum CA125,CA153,CA199 and CEA in the diagnosis of epithelial ovarian carcinoma(EOC).Methods The serum levels of CA125,CA153,CA199 and CEA were detected before operation in 54 cases of ovarian cancer and 68 cases of ovarial benign lesion and 55 healthy women as the con-trol group,by using chemiluminescent immunoassay(CLIA).The statistical software SPSS 13.0 and MedCalc 10.4.0.0 were used to retrospectively analyze the results.Results The sensitivity,specificity and accuracy of the single index detection and the com-bined detection were calculated.The sensitivity,specificity and accuracy of CA125 were 96.3%,64.7% and 78.7% respectively, which were higher than other single index′s.In the combine detection,the sensitivity and accuracy of the combined detection of CA125 and CA153 were 99.1% and 79.5% respectively,which were higher than those in the optimal single index CA125 and the other combined detection(P <0.05).Conclusion The combined detection of CA125 and CA153 is superior to the CA125 single in-dex detection in the diagnostic value for EOC.