ABSTRACT
A? plays a crucial role in Alzheimer's Disease and the soluble A? oligomers have been recognized as the emerging neurotoxins,which ultimately cause memory impairment and neuronal loss through different mechanisms.The development of novel drugs targeting A? oligomers indicates new and promising therapy approaches for AD.The pathological roles as the proximal toxins in AD and the compounds,targeting soluble A? oligomers,which are currently in preclinical and early clinical development,are reviewed.
ABSTRACT
Objective To study the effects of polysaccharide from Ecklonia kurome on pulmonary interstitial fibrosis induced by bleomycin in rats.Methods The pulmonary interstitial fibrosis model was established by endotracheal injection of bleomycin in rats.25,50,100mg?mL-1 doses of the polysaccharide from Ecklonia kurome were ig administered to the rats respectively,and the contants of hydroxyproline in rat lung were determined by kits at 0,3,7,14,28 d after the model was made.Results At 7,28d after the model was made,the treatment groups of middle and high doses compared with the model group showed signi-ficantly decrease of hydroxyproline level(P
ABSTRACT
Objective: To investigate the antitumor activity and immune enhancing effect of glycoprotein from Chlamys (Azumapecten) farreri (FGP). Methods: S 180 bearing mice were used as animal model. The effects of FGP on tumor weight and immune function were observed in S 180 bearing mice. Results: The results showed that FGP could markedly decrease tumor weight and promote the phagocytic rate of macrophages, NK activity and increase weight of immune organs. Conclusion: FGP can inhibit the growth of S 180 tumor and enhance cell mediated immune function. The antitumor effect of FGP may be related to its immune enhancing activity.