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【Objective】 To investigate the risk factors of frailty syndrome in elderly patients with acute coronary syndrome （ACS） and their impact on prognosis. 【Methods】 The elderly patients with ACS aged 65 and over， who were hospitalized in the Department of Cardiology and Geriatric Cardiology of The First Affiliated Hospital of Xi’an Jiaotong University from September 2020 to February 2021， were selected in the cross-sectional survey. The patients were divided into frailty syndrome and non-frailty syndrome groups via the Chinese revised version of Tilburg Frailty Scale. We collected the patients’ activities of daily living， nutrition， depression， sleep quality， total cholesterol， triglycerides， low-density lipoprotein， and adverse events during hospitalization and within 30 days of discharge. We then performed LOG-BINOMIAL regression to analyze the risk factors of frailty syndrome. 【Results】 A total of 250 elderly ACS patients were enrolled， and 118 patients were diagnosed with frailty syndrome with 47.2% prevalence of frailty syndrome. There was a significant difference in the average score between the frailty syndrome group and the non-frailty syndrome group （11.06±2.53 vs. 5.77±1.54， P<0.01）. Multivariate regression analysis revealed that age （PR=2.01 CI： 1.81-2.22， P<0.001）， hypertension （PR=1.20 CI： 1.09-1.30， P<0.001）， chronic kidney disease （PR=1.16 CI：1.04-1.29， P=0.012）， and NT-proBNP （PR=1.20 CI： 1.07-1.35， P=0.004） were risk factors for frailty syndrome in elderly ACS patients. The incidence of arrhythmia and pulmonary infection during hospitalization and the rate of readmission within 30 days after discharge were significantly higher in the frailty syndrome group than those in the non-frailty syndrome group （P<0.05）. 【Conclusion】 There is a higher incidence of frailty syndrome in elderly patients with ACS. Older age， hypertension， chronic kidney disease and high NT-proBNP can increase the risk of frailty syndrome. In clinical practice， attention should be paid to the above factors， and reasonable intervention should be provided in time.
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Objective To assess the effect of PCI on quality of life in very old CHD patients.Methods One hundred and ninety-six ≥80 years old CHD patients were divided into PCI group (n=92) and drug therapy group (n=104).Their clinical data were retrospectively analyzed.The patients were followed up for 12 months during which non-event survival rate,readmission rate,and incidence of recurrent arrhythmia,cardiogenic death,bleeding events were recorded.Results The incidence of 3-vessel lesions and serum creatinine level were significantly higher in PCI group than in drug therapy group (70.65％ vs 25.00％,82.63±25.35 μmol/L vs 71.09±22.71 μmol/L,P＜0.01).The non-event survival rate was significantly higher while the readmission rate was significantly lower in PCI group than in drug therapy group (66.30％ vs 50.96％,25.00％ vs 44.23％,P＜0.05).No significant difference was found in recurrent arrhythmia and cardiogenic death between the two groups (P＞0.05).Conclusion PCI can effectively improve the quality of life in very old CHD patients.
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Objective To study the protective effect of Trimetazidine on myocardial injury in mice.Methods 6 to 7 week-old male BALB/c mice were randomly divided into 3 groups at twelve for each group:normal saline (NS) group,ISO group and TMZ group,N.S group for blank control group,ISO group for damage group,TMZ as treatment group.After 4 weeks,cardiac index (HW/BW) was calculated,serum lactate dehydrogenase (LDH) activity were measured by enzyme standard method.Malondialdehyde(MDA) was detected by thiobarbituric acid method(TBA).Superoxide dismutase (SOD) activity were determined by WST-1 method.The concentrations of serum Klotho were measured by ELSIA.The cardiac muscular tissue was imbedded with paraffin and colored with HE,Massion and caspase-3.Results The experiment model meets the requirements.In TMZ groups' HW/BW,LDH activity and MDA level were significantly lower than those of the ISO group(P ＜ 0.01).SOD energy,concentration of Klotho was significantly higher than those of the ISO group(P ＜ 0.01).HE color results showed that the myocardial cell diameter of ISO group was obviously larger than that of NS group,combined with disordered muscle fibers and hyperplastic myocardial interstitial fibroblasts.The cardiomyocytes diameter of TMZ groups was much smaller than that of the ISO group.Masson color results showed that the level of collagen fiber distribution in the myocardial interstitial and hemal wall of TMZ group was lower than that of ISO group.Caspase 3 color results showed that the number of tan dye distribution was significantly lower in TMZ group than that of the ISO group(Color positive results showed obvious practical color distribution).Conclusion Trimetazidine could prevent myocardial injury and its mechanism might be related to raised Klotho level.
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Objective To investigate the role of klotho protein in the pathogenesis of hypertension. Methods We collected blood samples of 104 patients with hypertension and 61 people without hypertension admitted to our hospital between March and June 2009. Klotho protein and nitric oxide (NO) in blood serum were detected by ELISA and nitro-reductase methods. Results Klotho protein absorbance and NO were lower in hypertension group than in non-hypertension group (P
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Objective To observe the value of serum cardiac troponin Ⅰ(cTn-Ⅰ) on the diagnosis of acute myocardial infarction (AMI). Methods The serum cTn-Ⅰand CK-MB of 30 elderly patients(≥65 y) and 30 middle-aged patients(
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Objective To investigat the relationship between PON_1 192 Gln-Arg gene polymorphisms and coronary artery lesions in Shaanxi Han Chinese.Methods A total of 222 cases with one or more than two branches narrow(≥50%) and 164 cases with no coronary artery narrow(0.05).Conclusion There was no relationship between PON_(1) 192 Gln-Arg gene polymorphisms and Shaanxi Han patients with coronary heart disease.