ABSTRACT
Objective To investigate the effect of statins on the prognosis of senile diabetic patients with cerebral infarction.Methods Sixty-two elderly patients with diabetes mellitus and cerebral infarction admitted to Shantou Central Hospital from June 2016 to June 2017 were selected.Thirty patients who took atorvastatin(10 mg/d) six months before onset were selected as observation group.At the same time,32 cases of cerebral infarction who were not given statins were selected as control group.The risk factors on admission to hospital,fasting glucose,glycosylated hemoglobin,blood lipid levels and neural function defect were compared between the two groups.The nerve function defect was evaluated after treatment for 2 weeks.Results In the observation group,the rates of drinking,smoking,coronary heart disease,hyperlipidemia,previous stroke and hypertension were 20.00％,63.34％,50.00％,73.33％,40.00％,70.00％,respectively,compared with the control group (28.00％,65.63％,56.25％,71.88％,34.38％,75.00％),there were no statistically significant differences (x2 =0.121,0.213,0.197,0.195,0.142,0.139,P =0.327,0.644,0.542,0.530,0.475,0.453).The triglyceride,total cholesterol,low density lipoprotein cholesterol and high density lipoprotein cholesterol in the observation group were (3.68 ±0.81) mmol/L,(1.35 ±0.46) mmol/L,(2.65 ± 1.36) mmol/L,(1.38 ± 0.56) mmol/L,respectively,which in the control group were (5.45 ± 1.24) mmol/L,(1.83 ± 0.76) mmol/L,(3.89 ± 1.51) mmol/L,(0.92 ± 0.33) mmol/L,respectively,the differences were statistically significant between the two groups (t =5.621,5.825,4.916,5.103,P =0.012,0.013,0.022,0.020).The levels of blood glucose and glycosylated hemoglobin in the observation group were (6.58 ± 2.87)mmol/L,(7.18 ±1.48)％,respectively,which in the control group were (6.84 ± 3.14) mmol/L,(7.05 ± 1.49) ％,respectively,the differences were statistically significant (t =1.049,1.199,P =0.301,0.362).The national institutes of health stroke scale (NIHSS) scores of the control group before and after treatment were (15.2 ± 4.3) points and (4.9 ± 0.8) points,respectively,which were higher than those of the observation group [(14.8 ± 3.8)points and (7.1 ± 0.7)points],and the differences were statistically significant (t =4.879,5.268,P =0.028,0.016).Conclusion The primary prevention of statins can improve the blood lipid level and nerve function of senile diabetic patients with cerebral infarction,as well as reduce the degree of disability.
ABSTRACT
Objective@#To investigate the effect of statins on the prognosis of senile diabetic patients with cerebral infarction.@*Methods@#Sixty-two elderly patients with diabetes mellitus and cerebral infarction admitted to Shantou Central Hospital from June 2016 to June 2017 were selected.Thirty patients who took atorvastatin(10 mg/d) six months before onset were selected as observation group.At the same time, 32 cases of cerebral infarction who were not given statins were selected as control group.The risk factors on admission to hospital, fasting glucose, glycosylated hemoglobin, blood lipid levels and neural function defect were compared between the two groups.The nerve function defect was evaluated after treatment for 2 weeks.@*Results@#In the observation group, the rates of drinking, smoking, coronary heart disease, hyperlipidemia, previous stroke and hypertension were 20.00%, 63.34%, 50.00%, 73.33%, 40.00%, 70.00%, respectively, compared with the control group (28.00%, 65.63%, 56.25%, 71.88%, 34.38%, 75.00%), there were no statistically significant differences (χ2=0.121, 0.213, 0.197, 0.195, 0.142, 0.139, P=0.327, 0.644, 0.542, 0.530, 0.475, 0.453). The triglyceride, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol in the observation group were (3.68±0.81)mmol/L, (1.35±0.46)mmol/L, (2.65±1.36)mmol/L, (1.38±0.56)mmol/L, respectively, which in the control group were (5.45±1.24)mmol/L, (1.83±0.76)mmol/L, (3.89±1.51)mmol/L, (0.92±0.33)mmol/L, respectively, the differences were statistically significant between the two groups (t=5.621, 5.825, 4.916, 5.103, P=0.012, 0.013, 0.022, 0.020). The levels of blood glucose and glycosylated hemoglobin in the observation group were (6.58±2.87)mmol/L, (7.18±1.48)%, respectively, which in the control group were (6.84±3.14)mmol/L, (7.05±1.49)%, respectively, the differences were statistically significant (t=1.049, 1.199, P=0.301, 0.362). The national institutes of health stroke scale (NIHSS) scores of the control group before and after treatment were (15.2±4.3)points and (4.9±0.8)points, respectively, which were higher than those of the observation group [(14.8±3.8)points and (7.1±0.7)points], and the differences were statistically significant (t=4.879, 5.268, P=0.028, 0.016).@*Conclusion@#The primary prevention of statins can improve the blood lipid level and nerve function of senile diabetic patients with cerebral infarction, as well as reduce the degree of disability.
ABSTRACT
ObjectiveTo explore the effect of single glucocorticoid treatment and glucocorticoid joint cyclophosphamide treatment on thyroid-associated ophthalmopathy.MethodsRetrospective analysis of clinical data of 35patients used single glucocorticoid( single medicine group) and 16 patients used glucocorticoids joint cyclophosphamide(joint group) was carried out.ResultsThe effective rate of joint group(93.8％ ) was significantly higher than single drug group (68.6％) ( x2 =3.87,P ＜ 0.05).Simple using glucocorticoid had significant treatment effect at CAS score,prominent eyes degrees,soft tissue inflammation score,but the curative effect was significantly lower than the joint group ( P ＜ 0.05 ).The adverse reaction rate had no significant difference between two groups.ConclusionCompared to single glucocorticoid treatment,the glucocorticoid joint cyclophosphamide treatment had better effect and lower adverse reaction rate,especially suitable for patients who had no effect or low effect on hormone therapy.