ABSTRACT
Objective To study the effects of acarbose combined with metformin in the treatment of newly diagnosed type 2 diabetes mellitus and its effects on levels of glycosylated hemoglobin and serum cystatin C.Methods 76 patients with newly diagnosed type 2 diabetes mellitus were divided into observation group and control group according to the order of admission.The control group was treated with metfonnin,the observation group was treated with acarbose combined with metformin.The levels of blood glucose and serum cystatin C before and after treatment in the two groups were compared.The clinical efficacy and side effects were analyzed.Results After treatment,the total effective rate in the observation group was significantly higher than that in the control group[89.47％ (34/38) vs.63.16％ (24/38)] (x2 =7.280,P ＜ 0.05).After treatment,the levels of glycosylated hemoglobin,postprandial blood glucose,fasting blood glucose and serum cystatin C in the observation group were significantly lower than those in the control group[(6.78 ±0.81)％,(7.01 ±0.22)mmol/L,(5.12 ±0.32)mmol/L,(0.82 ±0.11)mg/L vs.(7.99 ±0.85) ％,(9.49 ± 0.61) mmol/L,(7.32 ± 0.54) mmol/L,(1.41 ± 0.22) mg/L] (t =6.353,23.576,21.606,14.787,all P ＜ 0.05).There was no significant difference in the incidence rate of adverse reaction between the observation group and the control group [15.79％ (6/38) vs.13.16％ (5/38)] (x2 =0.106,P ＞ 0.05).Conclusion Acarbose combined with metformin can effectively reduce the levels of glycated hemoglobin and serum cystatin C in patients with newly diagnosed type 2 diabetes mellitus.The clinical efficacy is good and the adverse reaction rate is low.
ABSTRACT
Objective To study the effect of danshao shugan granule combined with metformin in treatment of nonalcoholic fatty liver and its effects on lipid and uric acid metabolism.Methods 80 patients of nonalcoholic fatty liver who received therapy from February 2014 to February 2015 in our hospital were selected as research objects.According to random number table,those patients were divided into the observation group (n=40) cases in each group and the control group (n=40).The control group was treated with metformin, while the observation group was treated with danshao shugan granule combined with metformin.Then blood lipid level, FBG, FINS, IR, SUA level, SOD, MDA level, therapeutic effect of two groups after treatment were compared.Results After treatment, TG,TC in observation group was significantly less than the control group (P<0.05); FBG, FINS, IR, SUA levels in the observation group were significantly lower than the control group ( P<0.05 ); SOD level higher than the control group, MDA level significantly less than the control group (P<0.05); The total effective rate of observation group was statistically higher than that in the control group (P<0.05).Conclusion Danshao shugan granule combined with metformin is well for nonalcoholic fatty liver,which can improve the glucose, lipid, uric acid metabolism and insulin resistance, and can protect the liver function.