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Objective:To compare the diagnosis value of color echocardiography and high resolution CT for early left ventricular dysfunction.Methods:72 cases of left ventricular dysfunction patients in our hospital were chosen, and all of patients were detected with color echocardiography and high resolution CT inspection. Each patient was followed-up for 18 months and then to compare the diagnosis values of the two kind methods.Results: After 18 months follow-up review, the diagnostic accuracy of color echocardiography and high resolution CT were 95.8% (69/72) and 97.2% (70/72), respectively. Both of two methods were higher, and the difference was not statistically significant (x2=0.207,P=0.649). All sorts of cardiac function detection result, such as LVSV, LVEF, LVEDV and LVESV, were similar between color echocardiography and high-resolution CT, and the difference was not statistically significant (t=-0.775,t=1.387,t=-0.624,t=-1.209;P>0.05). Conclusion: Both of the diagnostic accuracy of color echocardiography and high-resolution CT for early left ventricular dysfunction were higher. All of them are worthy generalization and applying in clinical diagnosis for early heart failure.
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression and significance of platelet derived growth factor (PDGF) and its receptor (PDGFR) in liver tissues of patients with chronic hepatitis fibrosis and liver cirrhosis.</p><p><b>METHODS</b>The expression, distribution, quantitation, and correlation of PDGF-A, PDGF-B, PDGFR-alpha, PDGFR-beta, and alpha-SMA in the liver tissues were analyzed by immunohistochemical techniques in 21 patients with chronic hepatitis and 42 patients with liver cirrhosis.</p><p><b>RESULTS</b>In the liver tissues of chronic hepatitis and liver cirrhosis, PDGF and its receptor and alpha-SMA mainly distributed in the fibrotic septa and the infiltration area of inflammation, particularly in branch spindle-shaped cells (activated HSC). The expression of PDGF-B and PDGFR-beta was stronger than that of PDGF-A and PDGFR-alpha with a significant difference between them (P<0.05 approximately 0.01). The expression and distribution of alpha-SMA was basically identical with the expression and distribution of PDGF-A, PDGF-B and PDGFR-alpha, PDGFR-beta and quantitative analysis showed a positive correlation (r=0.606, P<0.001).</p><p><b>CONCLUSIONS</b>PDGF and PDGFR play a key role in liver fibrogenesis and development. The biologic effects of PDGF are elicited through activising HSC. Inhibiting PDGF and its receptor is a new approach to the treatment of liver fibrosis.</p>