ABSTRACT
Objective: We conducted a cohort study to investigate the association of three common SNPs of vascular endothelial growth factors [VEGF] gene [+1612G/A, -634C/G and +936G/C] with clinical outcome of osteosarcoma in a Chinese population
Methods: A prospective study was conducted. Genotyping analyses of VEGF -2578C/A, +1612G/A, -634C/G and +936G/C were conducted using polymerase chain reaction-restriction fragment length of polymorphism. Multivariate Cox proportional hazards models were used to calculate hazard ratio [HR] and 95% Cl of effect of each genotype of VEGF+1612G/A, -634C/G and +936G/C on PFS and osteosarcoma of osteosarcoma
Results: The good response rate was 52.29%, and 116 [68.7%] died during the follow-up period
Patients carrying the +936 CC genotype and C allele showed a significantly more response to chemotherapy than those carrying the wild-type genotype. In the Cox proportional hazards model, patients carrying the VEGF -634 T allele was associated with a significantly decreased risk of PFS and Osteosarcoma [OS]
Patients carrying the +936 CC genotype and C allele were associated with a significantly decreased risk of presenting progressive disease or death from osteosarcoma when compared with those carrying the wild-type genotype. However, we observed no significant association between the VEGF -2578C/Aand +1612A/G polymorphisms and PFS and Osteosarcoma [OS] in gastric cancer patients
Conclusions: We found that VEGF -634G/C and +936T/C polymorphisms may affect the prognosis of osteosarcoma patients. These finding may be useful for predicting the clinical outcome of patients with Osteosarcoma [OS]
Further studies are greatly needed to confirm the clinical significance of these results