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Biological matrix reference material is a reference material that combines the target material with the biological matrix. The biological matrix reference material has higher consistency with the authentic specimens in forensic toxicology, and its application has a positive effect on improving the accuracy of test results. This paper reviews the research on the matrix reference materials corresponding to three common biological test materials (blood, urine and hair). In order to provide reference for the development and application of biological matrix reference materials in forensic toxicology, this paper mainly introduces the research progress of preparation technology of biological matrix reference materials and some existing products and their parameters evaluation.
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Forensic Toxicology/methods , Hair , Body FluidsABSTRACT
[ Abstract ] Objective To explore the effect of 3D print-based navigation module assisted placement of thoracolumbar pedicle screws. Methods From January 2019 to May 2021, we received 70 thoracic and lumbar fracture patients, divided into 3D technical group and conventional method group according to the surgical method, with 35 patients in each group. In the 3D technology group, pedicle screws were placed under the sight of the navigation module, while in the conventional group, pedicle screws were placed under the conventional C-arm fluoroscopy. The amount of intraoperative bleeding and time of C arm were counted in each patient. According to the different number of pedicle screw implantation in each patient, the average amount of blood loss, time and C-arm fluoroscopy times of each screw implantation were compared between the two groups. Ideal screw angles were designed for patients in both groups before surgery. Compared with the preoperative design, the difference between preoperative and postoperative screw angle and head angle was calculated and set as the deviation value. Two sets of data were compared. Visual analogue score(VAS), Japanese Orthopaedic Association (JOA) score, Oswestry disability index(ODI), vertebral height recovery ratio and Cobb’ s angle were compared between the two groups. Results The amount of blood loss, required time and exposure times of C-arm in 3D screw implantation group were significantly lower than those in conventional screw implantation group(P0. 05); In terms of Cobb’s angle and vertebral height recovery ratio, the 3D technique group was better than the conventional method group (P<0. 05). Conclusion The 3D printed navigation module can assist the precise placement of thoracolumbar pedicle screws, shorten the operation time, reduce intraoperative bleeding and c-arm exposure times, facilitate the recovery of the injured vertebral height, improve the efficacy.
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OBJECTIVES@#To analyze the characteristics of diphenidol poisoning cases and to provide clues and technical means for the identification of such cases.@*METHODS@#Biological samples of 9 deaths caused by diphenidol poisoning were detected by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), and the characteristics of these cases were analyzed retrospectively.@*RESULTS@#Most of the deaths caused by diphenidol poisoning were young females. The dosage was between 60 and 300 tablets, and the mass concentration of diphenidol in the postmortem blood ranged from 0.87 to 99.00 μg/mL. There was no correlation between the dosage and the concentration of diphenidol in the blood.@*CONCLUSIONS@#Diphenidol poisoning has the characteristics of high concealment and lethality. More attention should be paid to suicide cases, and diphenidol should be recommended as a routine detection item to avoid missing detection.
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Female , Humans , Chromatography, Liquid/methods , Tandem Mass Spectrometry/methods , Retrospective Studies , Administration, OralABSTRACT
@#Abstract: The demand for reliable toxicological data of chemicals runs through every link of occupational health work. The prevention of occupational diseases involves high requirements for the standardization of chemical toxicity assessment in occupational health institutions. Good laboratory practice (GLP) emphasizes the integrity of the test process to trace and supervise the whole process of the test, which is conducive to the standardization of chemical toxicity identification. Therefore, the standardized construction of GLP laboratories is an important starting point for occupational health institutions to carry out chemical toxicity identification. In the construction and management process of GLP laboratories for chemical toxicity identification, occupational health institutions need to build a sound organization and operation system, carry out systematic training and assessment of personnel, establish standard operating norms and emphasize their importance, strengthen the management of facility environment and laboratory, pay attention to quality control and process supervision, and constantly improve their own ability level. To actively adapt to social development and market demand, to provide strong support for occupational health work.
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Objective@#To understand the current situation of road traffic injuries among primary and secondary school students in Mengzi city.@*Methods@#Using the cluster random sampling method, more than 9 000 primary and secondary school students from 20 primary and secondary schools in Mengzi city, were randomly sampled. A questionnaire survey was conducted on the occurrence of road traffic injuries in school students.@*Results@#A total of 9 197 students were surveyed, including 150 from road traffic injuries. The incidence rates of road traffic injuries was 1.63% among students in Mengzi city and 2.85% among junior high school students, with the high incidence in May. The leading places of injuries were village roads (38.00%), city roads (33.33%) and district roads (12.67%), respectively. 26.67% of the traffic injuries occurred on the way to or from schools, with riding on electric bicycle (52.00%) as the major cause and contusion/abrasion (75.33%) appeared as the major signs. Both lower and upper limbs plus multiple parts were accounting for 45.51%, 22.16% and 16.17%, respectively of all the injuries. 70.67% of all the cases with road traffic injuries in children, recovered after treatment. Children with road traffic injuries would stay in the hospital for up to 90 days but spent less than 30 000 Yuan.@*Conclusion@#The incidence of road traffic injuries among students in Mengzi city seemed relatively high, with junior high school students reached the highest. Riding electric bicycle appeared as the leading cause for traffic injuries in children in Mengzi city of Yunnan province.
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Objective@#To establish the model of the self-confidence, motivation and authoritative advice factors influencing the use of child restraint and use structural equation model to test it to provide scientific basis for promoting the advocacy of use of child restraint.@*Methods@#Using multi-stage cluster random sampling method, 9 112 parents from the family with one or more private cars and 0-6 years old children in Shanghai and Shenzhen were investigated about the use of child restraint. A theoretical model of the self-confidence, motivation and authoritative advice factors influencing the use of child restraint was constructed. The theoretical model was validated and quantitatively analyzed by structural equation model.@*Results@#The overall model accords with the expected theoretical model, and the goodness of model fit was fine. The indicators had met the standard. RMSEA=0.03, CFI=0.97. The standardization coefficients of each route showed statistical significance (P<0.05). The standardization coefficients of the influence of authoritative suggestions and motives on self-confidence were 0.45 and 0.30 respectively, and the standardization coefficients of the influence of self-confidence on the use of child restraint was 0.40. The standardization coefficient of the influence of authoritative suggestions on motivation was 0.61.@*Conclusions@#In the advocacy of the use of child restraint, we should attach importance to the use of recommendations from experts and organizations with professional authority, good credibility and public welfare. We should take the status of children’s road traffic safety and the mechanism of the role of child restraint as one of the key points of propaganda.
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Objective@#To understand the injuries among 16 459 left-behind children from 27 poor rural areas in 12 provinces of China, 2016.@*Methods@#Data were collected from the survey of 'Health Service Needs Assessment’ (HSNA) program on left-behind children, from poor rural areas in the middle and western parts of China. Factors including causes, types, locations, related activities, ways of treatment and outcomes among left-behind children with injuries in 2016, were described and analyzed by gender and age groups.@*Results@#In 2016, per-person and person-time incidence rates of injuries were 8.88% and 11.21%, among the 16 459 left-behind children from 27 poor rural areas in 12 provinces of China, both higher in boys, than in girls. Most injuries were unintentional with its proportion higher in older children. The main types of injuries were seen as falls, blunt and sharp injuries, with burns and animal injuries more common in younger children. Injuries among left-behind children mainly took place at home, kindergarten/school, and on the highways/streets/roads, during playing. Most common ways of treatment would include at the emergency settings, self-treated, with older children more likely to treat by themselves. Most injuries were cured.@*Conclusions@#In programs on prevention and control of injuries targeting the left-behind children in poor rural areas, special attention should be given to older boys, on falls and blunt/sharp injuries, at home or kindergarten/school. Education programs should pinpoint on self-rescue skills and guidance on kids by the parents, with behavioral norms and social support included. Related comprehensive prevention and control mechanism should be developed in families, schools and communities, with medical resources and insurance mechanism explored to serve these population and districts, including those left-behind children.
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Objective@#To analyze and compare the disease burden of falls in Chinese population aged 0-19, in 1990 and 2017.@*Methods@#Indicators including number of deaths, mortality rates, years of life lost due to premature mortality (YLL), years lived with disability (YLD) and disability-adjusted of life years (DALY), on falls, were gathered from the Global Burden of Disease (GBD) 2017 and used to describe the disease burden and corresponding parameters on falls, between 1990 and 2017, in China.@*Results@#In 2017, number of death, YLLs, YLDs, DALYs caused by falls were 5 321, 0.43 million person years, 0.14 million person years and 0.57 million person years respectively, among aged 0-19 group. Rates on standardized mortality, YLLs, YLDs and DALYs on falls were 1.76/100 000, 141.49/100 000, 46.99/100 000, and 188.48/100 000, respectively. The burden of falls decreased with the increase of age. Compared with 1990, disease burden of falls decreased in all age groups, both in male and female, with more seen in the lower age groups. Compared with 1990, the number of deaths, rates on YLLs, YLDs and DALYs caused by falls decreased by 65.08%, 46.63%, 47.38% and 36.33% respectively, in 2017. However, the YLDs rate increased by 73.31% between 1990 and 2017. The ratio of YLLs to DALYs decreased from 90.84% in 1990 to 75.07% in 2017, with a proportion as 17.36%.@*Conclusion@#Compared with 1990, although the disease burden of falls among aged 0-19 group showed a decreasing trend, falls still caused serious disease burden for the aged 0-19 group. Research that targeting prevention on falls, should be continued.
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OBJECTIVE@#To explore a method of modified incision to prevent the postoperative spinal lateral angulation via anterior approach for lumbar fracture.@*METHODS@#A total 40 patients with lumbar fracture from January 2016 to Jun 2017 were internalized in the study. Including 28 males and 12 females, aged from 27 to 68 years with an average of (39.5±14.9) years. Among them, 28 cases caused by high fall, 9 cases by heavy injury, 3 cases by traffic accidents; and 35 fractures were located at L₁,4 at L₂,1 at L₃. All the fractures were type A based on AO classification. According to Frankel classify of spinal cord injury, 5 cases were grade A, 1 case was B, 10 cases were C, 15 cases were D, 9 cases were E. The patients were divided randomly into modified incision groups and routine incision groups. All patients were treated with decompression, internal fixation and titanium mesh supported bone graft fusion via anterior approach. All the internal fixation materials were ANTERIOR (Medtronic Inc). Incision direction and incision plane were improved in modified incision groups. The coronal Cobb angle and the angle between the vertebral screw and the corresponding endplate were analyzed before and after operation.@*RESULTS@#Pre-and post-operative coronal Cobb angles were (1.20±3.26) °, ( 2.16±3.55)° in modified incision groups and(1.22±4.42)°, (3.91±3.78)° in routine incision groups respectively. And there was no statistical difference before operation, and there was statistical difference after operation between two groups(=0.017). There was no lateral angulation of more than 5 degrees in modified incision group, but there was lateral angulation of 5 to 10 degrees in routine incision group in 6 cases. The incidence of lateral angulation about 5 degrees after operation was significantly different between two groups (=0.010). There was significant difference in the angle between the proximal two vertebral screws and the corresponding endplate between two groups (0.05).@*CONCLUSIONS@#The improvement of incision direction and plane can effectively prevent the postoperative spinal lateral angulation via anterior approach for lumbar fracture.
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Adult , Aged , Female , Humans , Male , Middle Aged , Bone Screws , Fracture Fixation, Internal , Lumbar Vertebrae , Spinal Fractures , General Surgery , Thoracic Vertebrae , Treatment OutcomeABSTRACT
A previous study has indicated that Krüppel-like factor 7 (KLF7), a transcription factor that stimulates Schwann cell (SC) proliferation and axonal regeneration after peripheral nerve injury, is a promising therapeutic transcription factor in nerve injury. We aimed to identify whether inhibition of microRNA-146b (miR-146b) affected SC proliferation, migration, and myelinated axon regeneration following sciatic nerve injury by regulating its direct target KLF7. SCs were transfected with miRNA lentivirus, miRNA inhibitor lentivirus, or KLF7 siRNA lentivirus in vitro. The expression of miR146b and KLF7, as well as SC proliferation and migration, were subsequently evaluated. In vivo, an acellular nerve allograft (ANA) followed by injection of GFP control vector or a lentiviral vector encoding an miR-146b inhibitor was used to assess the repair potential in a model of sciatic nerve gap. miR-146b directly targeted KLF7 by binding to the 3'-UTR, suppressing KLF7. Up-regulation of miR-146b and KLF7 knockdown significantly reduced the proliferation and migration of SCs, whereas silencing miR-146b resulted in increased proliferation and migration. KLF7 protein was localized in SCs in which miR-146b was expressed in vivo. Similarly, 4 weeks after the ANA, anti-miR-146b increased KLF7 and its target gene nerve growth factor cascade, promoting axonal outgrowth. Closer analysis revealed improved nerve conduction and sciatic function index score, and enhanced expression of neurofilaments, P0 (anti-peripheral myelin), and myelinated axon regeneration. Our findings provide new insight into the regulation of KLF7 by miR-146b during peripheral nerve regeneration and suggest a potential therapeutic strategy for peripheral nerve injury.
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Animals , Female , Humans , Male , Rats , Cell Movement , Genetics , Cell Proliferation , Genetics , Disease Models, Animal , Ganglia, Spinal , Cell Biology , Gene Expression Regulation , Genetics , Physiology , HEK293 Cells , Kruppel-Like Transcription Factors , Genetics , Metabolism , MicroRNAs , Genetics , Metabolism , Motor Endplate , Genetics , Myelin P0 Protein , Metabolism , Nerve Regeneration , Genetics , Physiology , Nerve Tissue Proteins , Metabolism , RNA, Small Interfering , Genetics , Metabolism , Rats, Sprague-Dawley , Rats, Wistar , Sciatic Neuropathy , Metabolism , General Surgery , TherapeuticsABSTRACT
Objective To analyze the disease burden of injuries in Chinese children aged between 0-14-year-old,in 1990 and 2013.Methods Data derived from the Global Burden of Disease 2013 was used to analyze the disease burden of injuries among children aged between 0-14-year-old in each province of China,using relevant indicators including mortality and the rate on disability-adjusted life years (DALY).Results In 2013,the number of deaths,rates on mortality and DALY caused by injuries in children aged between 0-14-year-old were 73 766,29.46 per 100 000 and 2 449.36 per 100 000,respectively.Each indicator of injury burden appeared higher in boys than that in girls.With the increase of age,burden caused by injuries in each age group showed a decreasing trend.Provinces and autonomous regions as Xinjiang,Tibet,Gansu,Qinghai and Ningxia ranked the top 5 regions on both mortality rate and DALY rate among children aged between 0-14-year-old.The top 3 injury-related mortality rates and rate on DALY were drowning,road traffic injury and exposure to mechanic forces,among children.Compared to the disease burden of injuries in the 1990s,all indicators showed decreasing trends in children aged between 0-14-year-old,with girls more than boys,and variations in different age groups.In all areas of China,improvements were seen on intervention programs related to the injury-caused burden among children aged between 0-14-year-old,except for Ningxia,Yunnan and Chongqing.Conclusions During the last two decades,there had been significant improvements in reducing the injury-caused burden among the Chinese children aged between 0-14-year-old.However,injury is still the most important risk on health of children under 4-year-old,with boys in particular.Drowning and road traffic injury were the two leading causes of death in children aged between 1 and 14-year-old.
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Objective To analyze the disease burden of falls in Chinese population aged 70 and over,in 1990 and 2013 and to provide evidence for the development of prevention strategies on falls in the elderly.Methods Indicators including mortality rate,years of life lost due to premature mortality (YLL),years lived with disability (YLD) and disability-adjusted of life years (DALY) on falls,were gathered from the results of Global Burden of Disease 2013 and used to describe the disease burden of falls in China by calculating the changing rates on corresponding parameters in 1990 and 2013.Results In 2013,the number of deaths,YLLs,YLDs,DALYs caused by falls among Chinese population aged 70 and over were 48 800,0.44 million person years,0.30 millions person years,and 0.74 million person years,respectively.The standardized mortality rate,rates on YLLs,YLDs and DALYs of falls were 561.71 per 100 000,55.87 per 100 000,373.98 per 100 000 and 929.85 per 100 000,respectively.The burden of falls increased along with the increase of age.Compared with 1990,the number of deaths,YLLs,YLDs and DALYs caused by falls increased by 308.80％,161.01％,54.67％ and 104.47％,respectively,in 2013,more seen in males than in females.The standardized mortality rate,YLLs and DALYs caused by falls increased by 63.67％,38.54％ and 73.08％,respectively,during 1990 and 2013.However,the standardized YLDs rate fell by 17.90％ during the same period.Conclusion Falls caused heavy disease burden which increased in 1990 and 2013 among the Chinese population aged 70 and over.
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Objective To provide basic suicide prevention strategy through analyzing the disease burden of suicide in the Chinese population,in 1990 and 2013.Methods Indicators including mortality rate,years of life lost due to premature mortality (YLL),years lived with disability (YLD),and disability-adjusted of life years (DALY) on suicide,were from the results of Global Burden of Disease 2013 and used to describe the burden of disease caused by suicide in Chinese population.Data described the disease burden of suicide in China by comparing the corresponding parameters in 1990 and 2013.Results In 2013,the standard mortality on suicide was 9.08 per 100 000,and 73.39 per 100 000 in the 80 and above year-old,with the highest rates on DALY and YLL seen in the 75-79-year-old.Each parameter related to suicide burden in males appeared higher than that in females.Compare to data in the 1990s,these parameters declined in 2013,especially seen in females.The rate of YLLs/YLDs on suicide was 90.03 in 2013,89.83 in males and 89.00 in females.Conclusion The disease burden of suicide decreased sharply between 1990 and 2013 but was still a serious issue in the elderly that called for more attention.
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Objective To explore the disease burden of road injuries in China.Methods The results of Global Burden of Disease 2013 including death rate,disability-adjusted of life years (DALY),years of life lost due to premature mortality (YLL),years lived with disability (YLD),were used to describe the burden caused by road injuries in 2013 and the trends from 1990 to 2013,in China.Results In 2013,there were 313 676 deaths caused by traffic accidents in China.Death rate,rates on DALY,YLL and YLD were 22.52 per 100 000,1 076.54 per 100 000,971.21 per 100 000 and 105.34 per 100 000,respectively.Rates on deaths,YLL and YLD appeared higher in males,pedestrians than in females and other types of road travelers.Burden of injuries caused by traffic accidents was seen higher in those aged 15 to 49-year-old.From 1990 to 2013,the overall death rate on road injuries increased by 0.54 per 100 000 in China,with an increase of 2.34 per 100 000 and 0.81 per 100 000,respectively in males and pedestrians.The rates on DALY,YLL and YLD decreased by 164.21 per 100 000,115.06 per 100 000 and 49.06 per 100 000,respectively.Conclusions During the past 20 years,achievements had been made on road injury prevention and control,with the decrease of disease burden caused by road accidents.Males,young adults and pedestrians should be called for more attention to prevent road injuries.
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Objective To analyze the disease burden of violence in the Chinese population,in 1990 and 2013.Methods Indicators including mortality rate,years of life lost due to premature mortality (YLL),years lived with disability (YLD),and disability-adjusted of life years (DALY)related to violence,were extracted from the Global Burden of Disease 2013 and used to describe the burden of disease caused by violence in the Chinese population.Data related to corresponding parameters on disease burden of violence in 1990 and 2013 were described.Results In 2013,a total of 20 500 people died of violent events,with the death rate as 1.44 per 100 000,in China.DALY caused by violence was 1.08 million person years in 2013.DALY caused by sharp violence was 0.47 million person years,with 0.09 million person years lost due to firearm violence.Disease burden caused by violence appeared higher in males than in females.When comparing with data from the 1990s,reductions were seen by 67.35％ on the standardized death rate of violence,by 68.07％ on the DALY attributable to violence,and by 70.47％ on the standardized DALY rate attributable to violence,respectively,in 2013.Disease burden of violence among young adults and elderly was among the highest.When comparing with data from the 1990,DALY in 2013 decreased among all the age groups except for the 70-year-old showed an increase of 9.36％.The standardized DALY rate in 2013 showed a declining trend in all the age groups,mostly in the 0-4-year-old group.The standardized DALY rates caused by sharp violence or firearm decreased by 75.11％ and 83.20％ in the 0-4-year-old group.Conclusion In recent years,the disease burden caused by violence showed a decreasing trend but appeared higher in males however with the increase of DALY in the eldcr population.
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Objective To comprehensively analyze the disease burden of drowning in the Chinese population both at the national and provincial levels in 1990 and 2013,to provide reference for the development of strategies regarding drowning prevention.Methods Both methods related to unified measurement framework and standardized estimation on Global Burden of Disease in 2013,were used.Data on deaths caused by injuries were from the following sources which include:Disease Surveillance Points,the National Maternal and Child Health Surveillance Network,the Death Registration Reporting System of Chinese Center for Disease Control and Prevention,Death Registration System and death information from Macau and Hong Kong areas of China.Injury-related incidence data was from the National Injury Surveillance System and literature review.Parameters as death/death rate,years of life lost due to premature mortality (YLL)/standardized YLL rate,years living with disability (YLD)/standardized YLD rate and disability-adjusted of life years (DALY)/standardized DALY were used to analyze the disease burden and changing trend on drowning at both the national and all the provincial levels.Results In 2013,the number of deaths due to drowning was 63 619 in China,with the standardized mortality rate as 5.29 per 100 000,accounting for 8.0％ of the total injury deaths.Drowning was the fourth leading cause of injury death in the whole population and the first leading cause of injury death among children aged ＜ 5 and 5-14 years old in 2013,with YLL of drowning as 3.49 million person years,YLD as 0.04 million person years,and DALY as 3.53 million person years.Compared with data from 1990,the rates on standardized mortality,standardized YLL,standardized YLD and standardized DALY of drowning all declined in 2013.The five provinces/districts/cities with the highest rates of drowning were Xinjiang (10.08 per 100 000),Jiangxi (8.44 per 100 000),Anhui (7.92 per 100 000),Guizhou (7.77 per 100 000) and Sichuan (7.68 per 100 000).Standardized mortality of drowning reduced in all provinces in 2013.Conclusions Disease burden of drowning in the Chinese population,especially in children,declined significantly in 2013,comparing to 1990.However,drowning remains a serious proble,with children and males in particular,in China.Research regarding prevention on drowning is in great need in the western and central areas where drowning mortalities appeared high.
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Objective To understand the current status and change trend of violence against children in China and provide evidence for the risk factor and intervention priority identifications and intervention strategy development.Methods The data of National Injury Surveillance System (NISS) from 2006 to 2015 were used to analyze the change in outpatient visit due to violence against children,injury cases' demographic characteristics,incidence of injury and clinical outcomes of injury cases.Results A total of 44 319 injury cases caused by violence against children were reported through NISS during this period.The proportion of violence related child injury cases in total child injury cases decreased year by year.In child violence cases reported in 2015,boys accounted for 81.31％,the boy to girl ratio was 2.22 ∶ 1.Violence related injuries caused by blunt strike accounted for 65.69％.The incidences of child violence were low in February and during July-August and 48.87％ of violence related injuries occurred in schools and public places,bruise accounted for 63.52％.The main injured body part caused by child violence was head (51.18％),and most violence caused injuries (82.66％)were mild,while 83.21％ of the injury cases went home after treatment.Conclusions Violence against children should not be ignored.Male students of middle/high schools are at high risk.Schools are the places where violence against children is prone to occur.Health and safety education should be strengthened to prevent the occurrence of campus violence and improve the child' s awareness of self-protection and reduce the incidence of serious violence.
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Objective To analyze the burden and changes caused by burns among Chinese population,from 1990 to 2013.Methods Using the G20 data and the China national and subnational data from GBD2013,this study deemed to comprehensively show the burden caused by burns and the change from 1990 to 2013,using the indicators of death and DALY.Results In 2013,the standardized mortality of burns in Chinese was 0.88/100 000,with the standardized DALY rate of burn as 30.58/100 000.The ratio of DALY between males and females was 1.85 ∶ 1.Among the G20 countries,China ranked 16 for the standardized DALY rate,according to the top down order.The highest death rate was seen in the age group of 70 and over,followed by age group of 5,which had the highest DALY rate and followed by the 70 or older age group.In different provinces,Guizhou presented the highest DALY rate (50.24/100 000),with Aomen area the lowest (6.16/100 000).From 1990 to 2013,the burden of burn reduced generally.Both the standardized rates on death and DALY reduced by 68.10％ and 76.95％ respectively,more in females than in males.Standardized rates on death and DALY reduced among all the age groups,with the rates of reduction increasing by age.From 1990 to 2013,the DALY rate decreased in all the provinces.Conclusions The burden of burn decreased in Chinese population during 1990-2013.However,the burden of burn among children,elderly and males were still relatively high that called for closer attention.
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Objective To analyze the disease burden of injuries in Chinese children aged between 0-14-year-old,in 1990 and 2013.Methods Data derived from the Global Burden of Disease 2013 was used to analyze the disease burden of injuries among children aged between 0-14-year-old in each province of China,using relevant indicators including mortality and the rate on disability-adjusted life years (DALY).Results In 2013,the number of deaths,rates on mortality and DALY caused by injuries in children aged between 0-14-year-old were 73 766,29.46 per 100 000 and 2 449.36 per 100 000,respectively.Each indicator of injury burden appeared higher in boys than that in girls.With the increase of age,burden caused by injuries in each age group showed a decreasing trend.Provinces and autonomous regions as Xinjiang,Tibet,Gansu,Qinghai and Ningxia ranked the top 5 regions on both mortality rate and DALY rate among children aged between 0-14-year-old.The top 3 injury-related mortality rates and rate on DALY were drowning,road traffic injury and exposure to mechanic forces,among children.Compared to the disease burden of injuries in the 1990s,all indicators showed decreasing trends in children aged between 0-14-year-old,with girls more than boys,and variations in different age groups.In all areas of China,improvements were seen on intervention programs related to the injury-caused burden among children aged between 0-14-year-old,except for Ningxia,Yunnan and Chongqing.Conclusions During the last two decades,there had been significant improvements in reducing the injury-caused burden among the Chinese children aged between 0-14-year-old.However,injury is still the most important risk on health of children under 4-year-old,with boys in particular.Drowning and road traffic injury were the two leading causes of death in children aged between 1 and 14-year-old.
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Objective To analyze the disease burden of falls in Chinese population aged 70 and over,in 1990 and 2013 and to provide evidence for the development of prevention strategies on falls in the elderly.Methods Indicators including mortality rate,years of life lost due to premature mortality (YLL),years lived with disability (YLD) and disability-adjusted of life years (DALY) on falls,were gathered from the results of Global Burden of Disease 2013 and used to describe the disease burden of falls in China by calculating the changing rates on corresponding parameters in 1990 and 2013.Results In 2013,the number of deaths,YLLs,YLDs,DALYs caused by falls among Chinese population aged 70 and over were 48 800,0.44 million person years,0.30 millions person years,and 0.74 million person years,respectively.The standardized mortality rate,rates on YLLs,YLDs and DALYs of falls were 561.71 per 100 000,55.87 per 100 000,373.98 per 100 000 and 929.85 per 100 000,respectively.The burden of falls increased along with the increase of age.Compared with 1990,the number of deaths,YLLs,YLDs and DALYs caused by falls increased by 308.80％,161.01％,54.67％ and 104.47％,respectively,in 2013,more seen in males than in females.The standardized mortality rate,YLLs and DALYs caused by falls increased by 63.67％,38.54％ and 73.08％,respectively,during 1990 and 2013.However,the standardized YLDs rate fell by 17.90％ during the same period.Conclusion Falls caused heavy disease burden which increased in 1990 and 2013 among the Chinese population aged 70 and over.