ABSTRACT
The safety of occupational exposure to inhaled anesthetics remains a concern among the medical staff in hospitals. Few reports are seen about the impact of inhaled anesthetics on the reproductive system, particularly that of males. Several clinical and basic studies on isoflurane and others suggest that inhaled anesthetics affect the reproductive system of rodents by decreasing the sperm count, inducing sperm morphological abnormality, reducing sperm motility, and changing the levels of reproductive hormones, the underlying mechanisms of which are mainly associated with the alteration of the hypothalamic-pituitary-gonadal axis and DNA damage and apoptosis of reproductive cells. This article reviews the main impacts of inhaled anesthetics on the male reproductive system and the possible mechanisms.
Subject(s)
Humans , Male , Anesthetics, Inhalation , Pharmacology , Apoptosis , DNA Damage , Genitalia, Male , Isoflurane , Pharmacology , Occupational Exposure , Sperm Count , Sperm Motility , SpermatozoaABSTRACT
OBJECTIVE: To study the chemical constituents of Emilia sonchifolia. METHODS: The chemical constituents were isolated by Sephadex LH-20 and silica gel column chromatographies. Their structures were elucidated by spectroscopic data and physical-chemical properties. RESULTS: Ten compounds were isolated and their structures were established as 5, 7, 3'-trihydroxy-4'-methoxy flavone-3-O-α-L rhamnoside(1), apigenin-6, 8-di-C-β-D-Glucopyranoside (2), quercetin-3-O-α-L-rhamnoside (3), quercetin (4), aurantiamide acetate (5), obtucarbamate A (6), friedelin (7), stigmasterol (8), β-sitosterol (9) and daucosterol (10). CONCLUSION: Compounds 1-2, 5-7, and 10 were isolated from this genus for the first time.
ABSTRACT
OBJECTIVE@#To investigate the effect of fructose-1,6-diphosphete(FDP) on myocardial preservation in pulmonary operations.@*METHODS@#One hundred and six patients undergoing selective pulmonary lobectomy or segmentectomy were randomly divided into 2 groups with 53 patients each. FDP 200 mg/kg was infused intravenously before anesthesia in the FDP group, while 5% glucose with the same volume was given instead of FDP in the control group. ECGs were monitored from before the anesthesia to 72 h after the operation;the time and type of arrhythmia were recorded. Blood samples were taken before the operation (T0), immediately after the operation(T1), at 24 h(T2),48 h(T3)and 72 h(T(4)) after the operation to determine plasma creatine kinase isoenzyme MB(CK-MB) and cardiac troponin I(cTnI) concentrations.@*RESULTS@#The incidence of arrhythmia in FDP group (35 times) was significantly lower than that in the control group(67 times). The incidence of all types of arrhythmia in the FDP group was also significantly lower than that in the control group. The concentrations of CK-MB and cTnI in the FDP group were significantly lower than those in the control group at T1, T2, T3, and T4.@*CONCLUSION@#FDP is effective for myocardial preservation in pulmonary operations.