1.
Journal of International Pharmaceutical Research
;
(6): 677-681, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-845514
ABSTRACT
RNA interference (RNAi) is a method that allows double-stranded RNA (dsRNA) to induce the target gene mRNA to degrade in the body and lead to different levels of gene silencing. Small interfering RNA (siRNA) is the effector molecules of RNAi, and needs the delivery vehicle into the cells to play a therapeutic role. Nanoscale carrier can adjust the rate of drug release, increase permeability of biofilm, change distribution in the body, and improve bioavailability. In this manuscript, materials, structure and biological characteristics of existing non-viral nanometer vectors delivery for siRNA are summarized.