ABSTRACT
ObjectiveTo study the effect of Shenling Baizhusan on electrogastrogram in children with spleen deficiency diarrhea. To clarify the occurrence of gastric electrical rhythm disorder in children with this disease， and to study whether Shenling Baizhusan can improve the abnormal gastric motility in children with diarrhea （spleen deficiency） MethodA total of 125 children with spleen deficiency diarrhea in the outpatient department of Children's Hospital of Shanghai from October 2019 to March 2021 were selected as the research objects， and they were randomly divided into a control group （60 cases） and an observation group （65 cases）. The children in the control group were treated with Montmorillonite powder combined with probiotics treatment， and the children in the observation group were additionally treated with Shenling Baizhusan. The course of treatment for both groups was 1 week. The clinical efficacy of the two groups of children after treatment and the scores of main traditional Chinese medcine（TCM） symptoms before and after treatment were compared， and the changes in the main parameters of electrogastrogram in children before and after treatment were compared. ResultAfter treatment， the total effective rate of observation group （90.77%， 59/65） was higher than that of control group （76.67%，46/60） （χ2=4.617， P<0.05）. After treatment， scores of fecal morphology， frequency of defecation， fatigue， inappetence， and other symptoms in both groups were lower than that before treatment （P<0.05）， and the observation group was lower than the control group （P<0.05）. As compared with before treatment， the main frequency， the percentage of normal slow wave， and the percentage of normal gastric electrical rhythm in the two groups increased after treatment （P<0.05）， and the control group was lower than the observation group （P<0.05）. The proportion of children with slow gastric rhythm decreased （P<0.05） as compared with before treatment， and the control group was higher than the observation group （P<0.05）. ConclusionShenling Baizhusan can significantly relieve the diarrhea symptoms in children with spleen deficiency diarrhea and improve gastric motility with good clinical effects.
ABSTRACT
ObjectiveTo explore the clinical effect of modified Wuhutang in the treatment of children with acute asthma. MethodA total of 130 children with acute asthma were randomly divided into an observation group and a control group， with 65 cases in each group. The observation group was treated with modified Wuhutang and the control group was treated with procaterol hydrochloride for one week. The scores of primary symptoms （wheezing， cough， shortness of breath， and chest tightness） and secondary symptoms （mental status， runny nose， dry mouth， tongue texture， tongue coating， stool， etc.）， lung functions， immunoglobulin E （IgE） expression， eosinophil （EOS） count， and serum inflammatory factors， including interleukin （IL）-5， IL-6， IL-8， and IL-1β in two groups before and after treatment were compared. ResultThe data of 126 children were statistically analyzed. As revealed by the results， compared with the conditions before treatment， the scores of primary symptoms and secondary symptoms， serum levels of IL， IgE expression， and EOS count were both reduced in two groups （P<0.05）， lung functions were increased in the two groups（P<0.05）. Compared with the control group after treatment， the observation group showed decreased scores of cough and secondary symptoms （P<0.05）， and insignificant decrease in IL-1β （P<0.05）. The improvement in lung functions， IgE expression， and EOS count in observation group was equivalent to that in control group. ConclusionModified Wuhutang for treatment of acute asthma in children （phlegm-heat obstructing lung syndrome） can significantly relieve the clinical symptoms， improve lung functions， and reduce IgE， IL-5， IL-6， IL-8， IL-1β expression levels and EOS count， and its overall clinical efficacy is superior or equivalent to that of tprocaterol hydrochloride.
ABSTRACT
Objective To explore the role of…respiratory, syncytial virus (RSV) infection in aggravating airway inflammation and airway resistance in murine-asthma model. Methods A total of 30 6-8-week-old male BALB/c mice were equally divided into three groups randomly: thecontrol group,’ ovalbumin (OVA) group (asthma group), and respiratory syncytial virus (RSV)/OVA group (RSVh asthma group). In OVA group,murine asthma model was established using an OVA sensitization; in OSV/RSV group,mice were firstly sensitized by OVA and subsequently infected with RSV intranasally for three times to make acute viral infection asthma model ; and in control group, the mice received equal volume of PBS treatment. Twenty-four hours after the last challenge,the airway resistance was evaluated by mouse ventilator (Buxco RC). Inflammatory cell infiltration was measured in bronchoalveolar lavage fluid (BALF). Pulmonary tissue samples were collected and stained with H E,PAS or VG to observe inflammation of pulmonary tissues. Results Pulmonary tissue of mice in OVA group had inflammatory cell infiltration, airway mucus secretions were visible, and collagen was seen around the airway. Pulmonary tissue of mice in OVA/RSV group had significant inflammatory cell infiltration, alveolar stenosis, telangiectasia congestion,airway mucus secretions and collagen deposition. Lung function and the proportion of BALF eosinophils (EOS%) in OVA group and OVA/RSV group were significantly different from that of the control group (P<0. 05,7<0. 01). Airway resistance and the EOS% in OVA/RSV group were significantly different from those of the OVA group (P<0. 05). Conclusion RSV infection can aggravate the airway inflammation and result in airway resistance in murine asthma model.