ABSTRACT
<p><b>AIM</b>To study the protective role of endogenous carbon monoxide to lung and kidney tissues during septic shock and its mechanism.</p><p><b>METHODS</b>A rat model of CLP was built by using the method of CLP. The malondialdehyde (MDA) content and the activity of superoxide dematase (SOD) in blood, lung and kidney were detected by immunohistochemical technique and light microscope.</p><p><b>RESULTS</b>Pathological changes of lung and kidney in CLP + Hemin group were lighter than CLP group, inflammatory reaction and lipid peroxidation were also lighter.</p><p><b>CONCLUSION</b>Endogenous CO can protect lung and kidney from the oxidative injury. It can suppress in flammation and the oxidative injury caused by activated inflammatory cells, it is probably an important mechanism of its protective effects.</p>