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Objective: To observe the clinical efficacy of warm needling moxibustion plus spine subtle adjusting manipulation for cervical radiculopathy. Methods: A total of 70 patients with cervical radiculopathy were randomized into an observation group and a control group, with 35 cases in each group. The observation group was treated with warm needling moxibustion plus spine subtle adjusting manipulation, while the control group was treated with warm needling moxibustion alone. The treatments were performed three times a week, and for four weeks in total. The visual analog scale (VAS) was scored before and after treatment. And the clinical efficacy of the two groups was compared after treatment. Results: The total effective rate was 97.1％ in the observation group, versus 88.6％ in the control group. The difference between the two groups was statistically significant (P<0.05). After treatment, the VAS scores in both groups significantly decreased (P<0.01), and the score in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: Warm needling moxibustion plus spine subtle adjusting manipulation has a better effect in the treatment of cervical radiculopathy than warm needling moxibustion alone.
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Tuberculosis remains one of the top ten causes of death worldwide, which seriously endangered human health. Latent tuberculosis infection(LTBI) refers to the fact that there no active tuberculosis after human body is infected, but there is the risk of developing active tuberculosis. This article elaborates the advantages and disadvantages of LTBI treatment, and based on the reality of tuberculosis in China, it is suggested that the prevention and treatment of LTBI should be improved step by step and the treatment of LTBI should be promoted from are to point in China,so as to eliminate tuberculosis in latent infection, reduce the incidence of tuberculosis,and achieve the goal of END TB strategy by the World Health Organization by 2035.
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Objective To study the difference between scattered prick with three-edge needle and tapping prick with plum-blossom needle (seven-star needle) in treating cervical spondylosis of nerve root type by observing the content of serum tumor necrosis factor-α (TNF-α) in patients' peripheral blood. Method Sixty patients with cervical spondylosis of nerve root type were randomized into a three-edge needle group and a plum-blossom needle group. The three-edge needle group was intervened by scattered prick with three-edge needle, while the plum-blossom needle group was intervened by plum-blossom needle. The two groups were treated once a week, for 4 weeks in total. The level of TNF-αin serum of the two groups was measured before and after the treatment, and the clinical efficacies were compared. Result The level of serum TNF-α changed significantly after the treatment in both groups (P<0.05), but there was no significant between-group difference in comparing the level of serum TNF-α after the intervention (P>0.05). The between-group difference in the clinical efficacy was statistically insignificant (P>0.05). Conclusion Both three-edge needle and plum-blossom needle can significantly down-regulate the content of serum TNF-α in peripheral blood, and there is no noticeable difference between the two methods.
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<p><b>AIM</b>To observe the effect of homocysteine (HCY) on the function of endothelium cell, and to discuss the possible mechanisms that Tongxinluo super powder affected.</p><p><b>METHODS</b>Healthy male Wistar rats were divided into randomly the control group, the model group, the Tongxinluo group. The effect of Ach on isolated rat thoracic aorta in vitro was examined, the microcirculation was observed by microcirculation meter, the activity of SOD and GSH-PX and content of NO, MDA, ET, Ang II, TXA2, PGI2 was detected.</p><p><b>RESULTS</b>Compared with control group, the effect of Ach on isolated rat thoracic aorta in vitro weakened markablely (P < 0.01), the format and percentage that capillary dilated declined significantly (P < 0.05), after treatment with Tongxinluo powder, the effect of Ach on isolated rat thoracic aorta in vitro was improved obviously (p < 0.01), and the format and percentage that capillary dilated were increased compared with model group; comparing with the control group, the level of Ang II and ET, TXA2 in plasm increased obviously (P < 0.05, P < 0.01), while the content of PGI2 depressed manifestly (P < 0.05), at the same time, both content of NO and activity of SOD, (GSH-PX declined obviously (P < 0.001, P < 0.05). After treatment with Tongxinluo powder, the level of ET, AngII and TXA2 reduced significantly in different degree (P < 0.01), while the content of PGI2 appeared stepping up notably (P < 0.01), and both activity of SOD and NO level increased obviously (P < 0.01, P < 0.05).</p><p><b>CONCLUSION</b>(1) The high homocystein might cause the contracted and dilated function decreased, it might get involved in endothelium disfunction as a result of the massive free radicals production and diastolic-contract factors balance disorder induced by high homocystein. (2) Tongxinluo powder could improve the function of endothelium-dependment dilation induced by high homocystein, that associated with inhibitting the excessive production of free radicals, and improved function of endothelium.</p>
Subject(s)
Animals , Male , Rats , Aorta , Pathology , Drugs, Chinese Herbal , Pharmacology , Endothelium, Vascular , Pathology , Homocysteine , Pharmacology , Protective Agents , Pharmacology , Random Allocation , Rats, WistarABSTRACT
<p><b>AIM</b>To study the thermodynamics of precipitation reaction and kinetics between berberine and rheinic acid. The former is the main compound in rhubarb root or corktree bark, the latter is a representation of anthraquinone compounds that are the main kind compound in coptis rhizome. The precipitate produced in preparation of complex prescription of Chinese herbal medicines Xiexin decoction and Shaoyao decoction had made an appeal. The work should build a good basement for two decoctions research and development.</p><p><b>METHODS</b>Capillary electrophoresis (CE) and front analysis methods are used for determining two compounds' equilibrium concentration at different precipitate conditions to calculate the constants of thermodynamics and kinetics.</p><p><b>RESULTS</b>The molar ratio of berberine and rheinic acid in precipitate is 1:1. The solubility product constant Ksp = [B] [R] = (3.29 +/- 0.19) x 10(-9) mol2.L-2. The precipitate reaction is an endotherm process and Ksp shows less effect by temperature. The reaction occurred immediately even though the precipitate cannot be observed in time. The precipitate process in experiments is practically just an aging or grown process of the precipitate particles. High temperature can quicken the aging.</p><p><b>CONCLUSION</b>The precipitate in Chinese herbal medicines Xiexin decoction and Shaoyao decoction should be resulted from anthraquinone compounds and alkaloids. The reproductivity of capillary electrophoresis can be improved for simple sample by combining peak height measurement.</p>