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Purpose@#The evidence of adherence to cancer prevention guidelines and endometrial cancer (EC) risk has been limited and controversial. This study summarizes and quantifies the relationship between adherence to cancer prevention guidelines and EC risk. @*Materials and Methods@#The online databases PubMed, Web of Science, and EMBASE were searched for relevant publications up to June 2, 2020. This study had been registered at PROSPERO. The registration number is CRD42020149966. Study quality evaluation was performed based on the Newcastle-Ottawa Scale. The I2 statistic was used to estimate heterogeneity among studies. Egger’s and Begg’s tests assessed potential publication bias. Summary hazard ratios (HRs) and 95% confidence intervals (CIs) for the relationship between adherence to cancer prevention guidelines score was assigned to participants by summarizing individual scores for each lifestyle-related factor. The scores ranged from least healthy (0) to most healthy (20) and the EC risk was calculated using a randomeffects model. @*Results@#Five prospective studies (four cohort studies and one case‑cohort study) consisted of 4,470 EC cases, where 597,047 participants were included. Four studies had a low bias risk and one study had a high bias risk. Summary EC HR for the highest vs. lowest score of adherence to cancer prevention guidelines was 0.54 (95% CI, 0.40 to 0.73) and had a high heterogeneity (I2=86.1%). For the dose-response analysis, an increment of 1 significantly reduced the risk of EC by 6%. No significant publication bias was detected. @*Conclusion@#This study suggested that adherence to cancer prevention guidelines was negatively related to EC risk.
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Repeated IVF failure has been a pain pointin the assisted reproductive process.The fallopian tubehas long been considered as a conduit for transporta-tion,ignoring its important role in embryo implantation.The main reasons for the repeated failure of IVF areembryonic factors,endometrial receptivity and otherfactors.The article mainly focuses on the effects ofvarious types of fallopian tube lesions on the abovethree factors,and analyzes the relationship betweenvarious oviduct chronic inflammatory lesions and IVFfailure.IVFfallopian tube obstructionendome-
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OBJECTIVE: To explore the clinical characteristics,diagnosis,treatment,and prognosis of ovarian hernia.METHODS: The clinical data of 1 case of ovarian hernia admitted to Affiliated Shengjing Hospital,China Medical University,from 2018-07-18 were analyzed,and the related literatures at home and abroad were analyzed and summarized.RESULTS: The patient was 30 years old and visited hospital with the chief complaints of“1 d of vulva pain after assisted reproduction with 4 h of aggravation”.Ultrasonography showed that a 5.2 cm×3.6 cm×3.5 cm mass was seen in the left pubic mound,which was considered to be the vulva neoplasm. The pain was not significantly alleviated after the vaginal mass puncture treatment in the assisted reproductive department.MRI examination suggested ovarian hernia.High ligation repair of inguinal hernia and ovary repair were performed in emergency. Ovaries were successfully retained during the operation.A total of 6 cases have been reported by searching relevant literatures at home and abroad. The disease is often manifested as conscious inguinal mass,lower abdominal pain or asymptomatic.The treatment method is mainly surgery.For young women,early diagnosis and treatment should be made as soon as possible to preserve the ovary.CONCLUSION: Early diagnosis and treatment based on clinical symptoms is recommended to avoid misdiagnosis for young women with reproductive function.A multimodal and multidisciplinary approach is recommended to safely and effectively preserve ovarian function.
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OBJECTIVE: To investigate the effect of laparoscopic treatment for bilateral hydrosalpinx on ovarian reserve function and IVF-ET(in vitro fertilization and embryo transfer,IVF-ET)outcomes.METHODS: A retrospective analysis was performed in 84 patients with bilateral hydrosalpinx admitted to Shengjing Hospital Affiliated to China Medical University from January 2015 to January 2017.Group A underwent bilateral salpingectomy(21 cases)and group B underwent laparoscopic bilateral tubal proximal ligation distal ostomy(63 cases);group B1 included cases of tubal interstitial tubal ligation and distal ostomy(28 cases)and group B2 included cases of fallopian tube tubal ligation and distal ostomy(35 tubal ligation cases).RESULTS: There was no significant difference in anti-Mullerian hormone(AMH),follicle stimulating hormone(FSH),estradiol(E2),or FSH/luteinizing hormone(LH)levels between groups A and B(P>0.05),but the LH level of group A was higher than that of group B[(5.44±2.93)U/L vs.(3.20±1.40)U/L];this difference was statistically significant(P0.05).There was no significant difference in reproductive outcomes between groups B1 and B2(P>0.05).CONCLUSION: Compared with tubal ligation,salpingectomy can reduce ovarian reserve function to a certain extent;there is no significant difference in IVF-ET outcomes after tubal ligation at different locations.
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<p><b>OBJECTIVE</b>To investigate the effect of angiotension II (AngII) on the activation of NLRP3 inflammasome and the expression of interleukin-1β (IL-1β) in human umbilical vein endothelial cells (HUVECs).</p><p><b>METHODS</b>HUVECs cultured in vitro were treated with different concentrations of AngII for varying lengths of time to determine the optimal concentration and time for AngII exposure. To test the impact of different agents on the effect of AngII exposure, HUVECs were pretreated with AngII receptor blocker losartan, NAD(P)H inhibitor DPI and H(2)O(2) scavenger CAT, caspase 1 inhibitor YVAD, or NLRP3 siRNA for silencing NLRP3, and the protein levels of NOX4, NLRP3, caspase-1 and IL-1β in HUVECs were analyzed by Western blotting.</p><p><b>RESULTS</b>AngII treatment at the optimal concentration (10(-9) mol/L) for 12 h significantly increased the protein levels of NOX4, NLRP3, caspase1 and IL-1β in HUVECs. Pretreatment with losartan, DPI, CAT, YVAD, or NLRP3 siRNA all attenuated the effects of AngII on the cells.</p><p><b>CONCLUSION</b>AngII can induce vascular inflammation by promoting the production of reactive oxygen species and activating NLRP3 inflammasome to increase the protein expression of IL-1β in HUVECs.</p>