ABSTRACT
ObjectiveTo explore the formulation rules for the treatment of heart pain in the Medical Heart Enlightenment （《医学心悟》） from the perspective of the "Tangye Jingfa Tu"， thereby providing a way of thinking about the treatment of heart pain in traditional Chinese medicine （TCM） and the study of the Medical Heart Enlightenment. MethodThe "Tangye Jingfa Tu" contained in the Secrets for Auxiliary Cultivation Life： The Essential Method of Using Herbal Medicine for the Differential Treatment of the Five Zang Organs （《辅行诀五脏用药法要》） was used to analyze the nine prescriptions for heart pain in Volume Ⅲ of the Medical Heart Enlightenment by CHENG Guopeng in the Qing dynasty. A "table for analyzing the formulation of the nine prescriptions for heart pain" was developed. The analysis diagrams for decoction and meridian rules in nine prescriptions for heart pain were plotted and the compatible structure of the medicinal flavors was analyzed. ResultThe composition of Chenxiang Jiangqisan for the treatment of Qi-induced heart pain is "five pungent， four bitter， and two sweet drugs"， the composition of Shouniansan for the treatment of blood-induced heart pain is "five bitter， four pungent， three sweet， and one salty drugs"， the composition of Qingzhongtang for the treatment of heat-induced heart pain is "six bitter， three pungent， and two sweet drugs”， the composition of Jiangfutang with Cinnamomi Cortex for cold-induced heart pain is "three pungent and two sweet drugs"， the composition of Xiaobanxia modified with Fuling Tang for treating fluid retention-induced heart pain is "two pungent and two sweet drugs"， the composition of Baohetang for treating heart pain due to dietary stagnation is "five sweet， four pungent， four bitter， and one sour drugs"， the composition of Guipitang for the treatment of deficiency-induced heart pain is "eight sweet， four bitter， three pungent， and one sour drugs"， the combination of Huachongwan for the treatment of worm-induced heart pain is "seven bitter， six pungent， and four sweet drugs"， the composition of Shenzhusan， Congbaijiu， and Shengjiangtang for the treatment of resistance-induced heart pain is "eight pungent， four bitter， and two sweet drugs". ConclusionFrom the perspective of the "Tangye Jingfa Tu"， the Medical Heart Enlightenment is based on the compatibility principle of "pungent-bitter-sweet drugs" in the treatment of heart pain， with heart deficiency treated with salty drugs for tonifying， or bitter-sweet-salty drugs， and heart excess treated with bitter drugs for purging， or sweet-pungent-bitter drugs， mostly applying the transformation rules of five medicinal flavors， i.e.， "sweet-pungent-bitter drugs" and promoting the action of the pungent and sweet drugs acting on the spleen into the heart to relieve and purge the heart. In most cases， the treatment focuses on harmonizing the heart， liver， spleen， and kidneys， with an emphasis on the mother-child relationship and the application of the principles of the five elements generating and controlling each other. If the progression of the disease involves both the mother and child organs， the formulation should adhere to the compatibility rule of "the child organ makes the mother organ excess and the mother organ makes the child organ deficient".
ABSTRACT
Objective:To explore the medication regularity and prescription rule of Chinese herbal medicine in the treatment of cardiac failure.Methods:The China Patent Publication Notice of the State Intellectual Property Office (http://epub.sipo.gov.cn/) was rearched and retrievedfor Chinese herbal medicine for the treatment of heart failure. The Traditional Chinese Medicine (TCM) inheritance support system (V 2.5) was used to input the prescription information and establish the database. The association rules, mutual information method, entropy clustering of complex systems and other data mining methods were used for commonly used drugs, combination rule and new prescription of core group.Results:A total of 101 prescriptions were included, involving 316 drugs. The frequency of commonly used drugs were Astragali Radix (59.41%), Poria (41.58%), Salviae Miltiorrhizae Radix et Rhizoma (40.59%), Descurainiae Semen Lepidii Semen (34.65%), Aconiti Lateralis Radix Praeparata (33.66%), and the medicinal properties were mainly warm, and the sweet taste. The main flavors weresweet, bitterness, and pungency, and the main sources of meridians belonged to liver, spleen, heart, lungs and kidneys. The most commonly used drug combinations contribute to supplement Qi, invigorate blood circulation and stasis, warm Yang, remove moisture. There were 12 core drug groups and 6 new prescriptions for heart failure. Conclusions:Analysis on formulas for heart failure shows that the prescriptions focus on supplementing qi and activating blood circulation, warming Yang reducing dampness, invigorating spleen, and nourishing Yin, dispel turbid, solid Yang. It can provide reference for clinical treatment to improve curative effect and standardize prescription medication.
ABSTRACT
Cases with coronary heart disease after successful PTCA were selected for observation of the preventive' action of CXZP on restenosis of the vessel. Results revealed that (1) In the western medicine group 15 cases experienced recurrent angina pectoris. Among them, 12 cases received repeated angiography, 11 of them were confirmed to have restenosis while the 3 other cases were positive in ECG exercise treadmill test. No obvious changes were observed in stasis integration before and after treatment (P
ABSTRACT
In addition to Routine Remedy for Angina Pectoris for all the patients. Refined Xue Fu Capsules and Xue Fu Capsules were prescribed for the first group (N = 30) and the second group (N = 34). The third group (N = 27) received only routine remedy as control in this single - blinded clinical trial. The total effective rate in these three groups were 96. 6%, 73. 5% and 70. 4%. The effect in the first group was significantly higher than the rest two groups (P
ABSTRACT
Rabbit model of arteriosckrosis of iliac artery was used in this experiment. Results showed: after 4 weeks of PTA operation, the calibre of the artery in large dose concentrated pill (LCP) group was obviously larger than that of the western drug group and Lovastatin group (P