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Alzheimer′s disease (AD) is an incurable disease in the field of major chronic diseases. Subjective cognitive decline (SCD) is a clinical risk factor for AD. The standardized screening and intervention in individuals with SCD are of great importance in early prevention and treatment of AD. According to the clinical criteria proposed by The characterisation of subjective cognitive decline, which was published online in Lancet Neurology, the article summarized the definition of SCD, the latest perspective of clinical standards in SCD, and the results of AD preclinical SCD research. The purpose of this work was to provide concrete guidance and recommendations for making clinical decisions in diagnosis and scientific research on SCD.
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Objective:To investigate the effects of Resolvin D1 (RvD1) on the inflammatory response and the expression of Nod-like receptor protein 3(NLRP3) inflammasomes in mice with acute lung injury.Methods:The 30 male BALB/c mice weighing 25-30 g were divided into 3 groups(each group with 10 mice). Mice in the normal control group were given normal saline by tail vein injection.Mice in the lipopolysaccharide (LPS) group were given the same volume of LPS (10 mg/kg) via tail vein injection.Mice in the RvD1 group were injected with RvD1 (5 μg/kg) through the tail vein 30 minutes prior to LPS administration.Mice were humanely sacrificed after 6 hours.Histopatholo-gical changes of lung tissue, the levels of pro-inflammatory cytokines interleukin(IL)-18 and IL-1β, and the expression of NLRP3 inflammasomes in lung tissue were measured.Results:After LPS administration, the lung of mice showed pathological damage.The levels of pro-inflammatory factors IL-18 and IL-1β as well as the expression of NLRP3, apoptosis-associated speck-like protein containing a card(ASC)and Caspase-1 in the LPS group were significantly higher than those in the normal control group (all P<0.05). After pretreatment with RvD1, the pathological damage of lung tissue was alleviated.The levels of pro-inflammatory factors IL-18 and IL-1β as well as the expression of NLRP3, ASC and Caspase-1 in the RvD1 group were significantly lower than those in the LPS group (all P<0.05). Conclusions:RvD1 can attenuate the pulmonary inflammation in acute lung injury and inhibit the release of pro-inflammatory factors, which is possibly related to the suppression of NLRP3.
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<p>Endolymphatic hydrops, regarded as a marker of Ménière's disease, can now be diagnosed using MRI. Since endolymphatic hydrops is considered a condition of fluid disturbance known as <i>suidoku </i>in Kampo medicine, Kampo preparations with a water flow smoothing ability are often used to treat endolymphatic hydrops. However, the hypothesis that endolymphatic hydrops is <i>suidoku </i>indication has not been fully tested. We used traditional Chinese medicine to diagnose patterns in 11 patients who had been diagnosed with endolymphatic hydrops using MRI. Additionally, we researched the literature regarding the condition of fluid disturbance and resulting vertigo. Of the 11 patients, seven showed disorder of fluid, eight showed kidney (traditional medicine, TM) disorder, and five showed liver (TM) disorder. According to the literature, the vertigo condition caused by fluid disturbance was described in the chapters “tanyinkesoubing and shuiqibing” in the “Jinguiyaolue”. Since no auditory symptom is mentioned in these chapters on vertigo, vertigo caused by fluid disturbance might differ from typical Ménière's disease with auditory symptoms. It is suggested that the patients with endolymphatic hydrops do not necessarily indicate <i>suidoku </i>and we should consider the states of kidney (TM) and liver (TM) disorders.</p>
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Objectives: To evaluate the physical strength, cerebral function, and mental health conditions in elderly persons, and to examine the correlation between these functions. Methods: The subjects were 151 independent-living elderly Japanese women, mean age 70 +/− 5 years (+/− SD; range, 60 to 80 years), with normal abilities in daily life. The health check-up was conducted from April to May 1997. Physical strength was estimated by measuring seven activities. Cerebral functions were assessed by six sub-tests of the General Aptitude Test Battery (GATB). Their mental health status was measured by four sub-scales of the General Health Questionnaire (GHQ)-28. Results: The physical strength and almost all of the cerebral functions decreased with age. Social dysfunction and severe depression on the GHQ sub-scales also worsened with age. Physical strength was strongly correlated with cerebral functions after adjusting for the confounding effect of aging. There were also interrelations between physical strength and mental health. Conclusions: This study provided important information on the correlation between physical and mental status in elderly women. Future longitudinal studies with the intervention of physical training are required to determine whether a causal relationship exists between these factors.
Subject(s)
Mental Health , AgedABSTRACT
<p><b>OBJECTIVES</b>To evaluate the physical strength, cerebral function, and mental health conditions in elderly persons, and to examine the correlation between these functions.</p><p><b>METHODS</b>The subjects were 151 independent-living elderly Japanese women, mean age 70 +/-5 years (+/-SD; range, 60 to 80 years), with normal abilities in daily life. The health check-up was conducted from April to May 1997. Physical strength was estimated by measuring seven activities. Cerebral functions were assessed by six sub-tests of the General Aptitude Test Battery (GATB). Their mental health status was measured by four sub-scales of the General Health Questionnaire (GHQ)-28.</p><p><b>RESULTS</b>The physical strenght and almost all of the cerebral functions decreased with age. Social dysfunction and severe depression on the GHQ sub-scales also worsened with age. Physical strength was strongly correlated with cerebral functions after adjusting for the confounding effect of aging. There were also interrelations between physical strength and mental health.</p><p><b>CONCLUSIONS</b>This study provided important information on the correlation between physical and mental status in elderly women. Future longitudinal studies with the intervention of physical training are required to determine whether a causal relationship exists between these factors.</p>