ABSTRACT
Objective To evaluate the efficacy and safety of deoxyribonucleotide in intervention with wound healing.Methods A total of 144 patients above Type Ⅱ incision was included.All patients were received conventional therapy.And 72 cases in positive group were given thymopentin 1mg/d for 7 ～14 days,72 patients in treatment group were given deoxyribonucleotide 200mg/d for 7 ～ 14 days.Wounds were observed at 7,14,30 days,respectively.Results Postoperative infection rate(12.1％ vs 16.6％ vs 40％,P ＜ 0.05),pathogenic bacteria detection were decreased by both treatment and control groups.The 14 d complete healing rate (80％ vs 48.3 ％,P ＜ 0.05),weight gain [(2.1 ± 0.7) kg vs (0.6 ± 0.3) kg,P=0.016],clinical effect (89.3％ vs 61.3％,P =0.0018) of treatment group were higher than the control group.The 7 d wound area and complete healing time of treatment group were lower than the control group [(12.6 ±6.8)cm2 vs (18.7 ±7.1)cm2,P =0.018; (18.8 ± 11.2)d vs (21.4 ± 12.6)d,P =0.023].Deoxyribonucleotide can promote fibroblast proliferation and collagen production [(35.4 ± 7.6)ng/L vs (24.4 ± 6.9) ng/L,P =0.006].Conclusions Short-term application of deoxyribonucleotide and thymopentin can decrease postoperative infection through activating immune function.However,wound healing had no relationship with activating immune function seemly.Deoxyribonucleotide promotes wound healing through promoting fibroblast proliferation.
ABSTRACT
Purpose:To study the clinical value of preoperative examination of P16 protein , immunohistochemical method was used to examinate the expression of the protein in tissues obtained through the fibrobronchoscopic brushing and biopsy.Methods:All of the patients who found lesions of lung by radiology were gotten the fibrobronchoscopy to get the spicements. All of the specimens were examinted for expression of P16 protein. The expressions of P16 protein in lung carcinoma group , benign lung disease group and blind biopsy group were compared.Results:The positive expression rates of p16 protein of lung carcinoma group , lung benign disease group and blind biopsy groups are : 55.0%, 95.0% and 62.5%. Conclusions:Difference was found between malignant and benign lung diseases.Examination of p16 protein expression for blind biopsy groups has some values in diagnosis of lung carcinoma.