ABSTRACT
Objective To investigate influencing factors of serum small and dense low-density lipoprotein cholesterol (sd LDL-C) levels in patients with chronic diseases in Zhoujiadu community, and to provide a scientific basis for the treatment of sd LDL-C related chronic diseases. Methods A total of 200 patients with common chronic diseases who were admitted to our hospital from November 2017-November 2019 were selected. Basic data including height, weight, past medical history and family history of the patients were collected. Biochemical indicators were measured to understand dietary structure. The influencing factors of serum sd LDL-C were analyzed by multiple stepwise regression. Results The levels of serum sd LDL-C in patients with advanced age, increased BMI, thickened IMT, fatty liver and coronary heart disease were significantly increased (P<0.05). Pearson linear correlation analysis showed that serum sd LDL-C level of patients with chronic diseases was positively correlated with TC, TG, LDL, ALT and AST, and negatively correlated with HDL (P<0.05). Multiple linear regression showed that TG, BMI, IMT, fatty liver, oil heating (frying and frying) and the use of mixed oil were independent risk factors of sd LDL-C level in patients with common chronic diseases, while HDL-C was a protective factor (P<0.05). Conclusion The levels of serum sd LDL-C in patients with common chronic diseases in Zhoujiadu community were correlated with dyslipidemia, BMI, thickening of IMT, fatty liver, oil heating (frying and frying), and use of mixed oil.