Role of long noncoding RNAs as competitive endogenous RNA in cerebral ischemia / 国际脑血管病杂志

Ischemic stroke is a common clinical cerebrovascular disease with the characteristics of high incidence rate, high mortality rate, and high disability rate. Recent studies have shown that noncoding RNAs (ncRNAs) are involved in the pathogenesis of ischemic stroke. By competitively binding miRNAs, it regulates neuronal apoptosis, inflammatory response, angiogenesis and blood-brain barrier damage in the process of ischemic brain injury. This article reviews the role of long noncoding RNAs (lncRNAs) as competitive endogenous RNAs in the pathophysiology of ischemic stroke.