ABSTRACT
PURPOSE: Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma. MATERIALS AND METHODS: Immunohistochemistry was used to evaluate the expression of pan-cytokeratin (CKpan), cytokeratin (CK) 7, thyroid transcription factor 1 (TTF-1), vimentin, epithelial membrane antigen (EMA), thyroglobulin, CD15, S100, P40, CK20, CDX-2, glial fibrillary acidic protein (GFAP), and Ki-67. Additionally, in situ hybridization investigation was utilized to identify the presence of small Epstein-Barr virus (EBV)–encoded RNA. RESULTS: Histopathological analysis revealed florid proliferation of papillary structures lined by columnar epithelial cells with fibrovascular cores. Immunohistochemically, the neoplastic cells were positive for CKpan, CK7, TTF-1, vimentin, and EMA, but negative for thyroglobulin, CD15, S100, P40, CK20, CDX-2, and GFAP. The Ki-67–labeling index reached 5% in the most concentrated spot. In situ hybridization for EBV was negative. CONCLUSION: Due to the distinct rarity of low-grade thyroid-like papillary adenocarcinomaswith a favorable clinical outcome, a nationwide effort to raise public awareness of this neoplasm is required.
Subject(s)
Adolescent , Female , Humans , Adenocarcinoma, Papillary , Asian People , Epithelial Cells , Glial Fibrillary Acidic Protein , Herpesvirus 4, Human , Immunohistochemistry , In Situ Hybridization , Keratins , Mucin-1 , Nasopharynx , RNA , Thyroglobulin , Thyroid Gland , Transcription Factors , VimentinABSTRACT
After-class reading is one of the important activities in the college students' spiritual life.The interests,sorts of books,contents and quantities of their reading can reflect their ideological conditions and their value judgment.Based on the investigation and analysis on their after-class reading activities,we can discover problems and give appropriate guidance in time,hoping to promote the cultivation of good after-class reading atmosphere on campus. The results of this survey can provide reference for the humanistic quality education of medical students.