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Objective:To investigate differences in the value of three chronic kidney disease epidemiology collaboration(CKD-EPI)estimation formulas in the evaluation of renal function damage in elderly patients with hypertension.Methods:A total of 58 patients with essential hypertension over 65 years of age were enrolled from November 2018 to March 2019 in this retrospective analysis.Patients with abnormal results in one or more items out of serum creatinine(Scr), blood urea nitrogen and urine protein were included in the hypertensive renal damage group(the positive group, n=25)and patients without abnormal results were included in the simple hypertensive group(the negative group, n=33). We measured Scr and cystatin c(Cys C)levels in fasting blood for each group.The estimated glomerular filtration rates(eGFR Scr, eGFR Cys C and eGFR Scr-Cys C)were calculated using the CKD-EPI formulas. Results:There was no statistically significant difference in gender, age, body mass index, grade of hypertension, onset time of hypertension, total cholesterol and triglycerides between the two groups( P> 0.05). There were significant differences in Cys C, eGFR Scr, eGFR Cys C and eGFR Scr-Cys C between the two groups( P<0.05). Spearman correlation analysis showed that Cys C was positively correlated with Scr( r=0.427, P<0.01), serum urate( r=0.266, P<0.05)and blood urea nitrogen( r=0.357, P<0.01)and was negatively correlated with eGFR Scr( r=-0.369, P<0.01), eGFR Cys C( r=-0.982, P<0.01)and eGFR Scr-Cys C( r=-0.845, P<0.01). Of the three formulas, eGFRScr-Cys C had the largest area under the receiver operating characteristic(ROC)curve(AUC)and its value was 0.707(0.565, 0.849). Conclusions:For the three estimation formulas, CKD-EPI Scr-Cys C has slightly better diagnostic efficiency than the others and may help improve the diagnosis of renal damage in elderly patients with hypertension.
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Objective:To investigate the correlation between lipoprotein(a)[Lp(a)]levels and parameters for left ventricular structure in elderly hypertensive patients.Methods:A total of 65 patients aged ≥65 years diagnosed with essential hypertension were enrolled in this retrospective analysis.Left atrial diameter dilation(LAD)was measured to evaluate the degree of cardiac involvement.According to the existence of LAD, patients were divided into the negative group(n=43)and the positive group(n=22). The differences in levels of blood lipids including Lp(a)and LAD as well as other echocardiographic indexes between the two groups were compared, and their correlations were analyzed.Results:Compared with the negative group, the duration of hypertension, LAD, and Lp(a)level increased in the positive group( P<0.05). LAD was correlated with age, duration of hypertension, left ventricular end diastolic diameter and Lp(a)level.The Lp(a)level was correlated with age and LAD( P<0.05). Logistic regression analysis showed that duration of hypertension( OR=1.060, 95% CI: 1.008-1.116)and Lp(a)level( OR=6.394, 95% CI: 1.038-39.396)were independent risk factors for LAD.The area under the receiver operating characteristic(ROC)curve of Lp(a)for LAD was 0.665(0.524, 0.806). Conclusions:Laboratory testing for serum lipoprotein(a) levels will help assess the degree of cardiac involvement in patients with hypertension and has practical value for the risk assessment of cardiac remodeling in elderly hypertensive patients.
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AIM:To observe the intervention effects of formononetin (FOR) on castration osteoporosis in rats,and the mechanism of osteoporosis prevention.METHODS:The bilateral ovariectomy was performed on female rats to induce osteoporosis rat model.Sixty female SD rats were divided into normal control group,osteoporosis model group,estradiol group (50 μg/kg) and formononetin in high,medium and low dose group (160,80,40 mg/kg),10 rats in each group.except the control group,All groups were administered with estradiol or formononetin treatment,(1 time a day) for 12 weeks one week after operation;rats serum tartrate resistant acid phosphatase (TRACP),change Ca2 +,Mg2 + and other indicators were detected 24 h after the last injection;the left femur was observed to detect MMP-9 and TNF-α,IL-6 mRNA expression by RT-PCR;Western-blot was used to detect P38MAPK,total bone tissue phosphorylation of P38MAPK,MMP-9,TNF-α,IL-6 protein;the right femoral bone was observed for density (bone mineral densit Y,BMD)determination.RESULTS:Compared with osteoporosis model rats,formononetin high dose group can increase the bone density of rats with osteoporosis,lower TRACP content in serum of rats with osteoporosis,and increase serum Mg2 +,Ca2 + content,reduce MMP-9,TNF-α and the bone IL-6,mRNA expression regulated by phosphorylation;P38MAPK mRNA protein expression.CONCLUSION:Formononetin has a good preventive and therapeutic effect on ovariectomized osteoporotic rats,and its mechanism may be related to inhibiting MMP-9 synthesis and secretion,osteoclast bone resorption and regulating P38-MAPK/MMP-9 signaling pathway.