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Objective To systematically evaluate the clinical efficacy and safety of Danshen Chuanxiongqin Injection (DCI) in the treatment of angina pectoris. Methods Randomized controlled trials (RCTs) regarding DCI in the treatment of angina pectoris were searched in CNKI, VIP, Wanfang Database, CBM, PubMed, Embase and Cochrane Library by Feb. 2014. Two researchers independently retrieved the RCTs and extracted the information. The Cochrane risk of bias method was used to assess the quality of the included studies, and a meta-analysis was conducted with Review Manager 5.2 software. Results A total of 12 RCTs with 1145 participants were included. The meta-analysis indicated that the combined use of DCI and conventional treatment with western medicine was more effective in the outcomes of the total clinical effective rate [RR=1.27, 95%CI (1.19,1.35), P<0.000 01], the total effective rate of ECG [RR=1.34, 95%CI (1.23,1.46), P<0.000 01], and decrease of plasma viscosity [MD=-0.15, 95%CI (-0.25,-0.05), P=0.004] and fibrinogen [MD=-0.96, 95%CI (-1.14,-0.78), P<0.000 01]. And there were no adverse drug reaction reports. Conclusion Based on this systematic evaluation, DCI combined with conventional therapy is effective and relatively safe in treating angina pectoris, but it still needs larger samples, multi-center, and high quality RCT to verify.
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Objective To investigate the epidemiological characteristics of adverse drug reactions (ADRs) induced by Chinese herbal injection for tonify, and provide reference for safety evaluation and rational use. Methods The ADR cases that issued on the domestic medicinal periodicals from 1972 to 2011 in China were collected comprehensively to build a database, and analyzed by statistic methods. Results Totally 233 ADR cases involving 7 different kinds of Chinese herbal injection for tonify were collected, in which 86 cases weighted the most were related to Huangqi Injection. Chinese herbal injection for tonify may induce multiple systematic ADRs. The incidence of respiratory damage was 27.0%(80 cases), which was dominated in the ADRs. The incidence of ADRs had no difference between the genders (male was 117 cases, 50.2%, and female was 116 cases, 49.8%), and the average age of patients was (51.40±16.67) years old. ADRs often occurred within half an hour after the start of infusion (64.5%). The diseases of patients mostly were cancer (19.3%), coronary heart disease (15.9%), and hypertension (6.0%), etc. Only 76 cases mentioned the combination therapy, which mainly combined with the drugs of antibiotics, other traditional Chinese medicines and vitamin. Conclusion ADRs of Chinese herbal injection for tonify are always induced by drug combinations, inappropriate medication, and other factors. To use Chinese herbal injection more rational and enhance prevention awareness may be the key to reduce the occurrence of ADRs.
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Objective To explore the medication rules of state medical master Yan Zhenghua from the prescriptions. Methods After analyzed by the statistical report module and the data analysis module, the method of data-mining that including association rules and apriori algorithm was used to analyze the frequency of Poria and drug combination, the association rules between drugs and core drug combinations in Pro. Yan’s prescriptions via a database based on Traditional Chinese Medicine (TCM) inheritance assist system. Results The prescriptions containing Poria were commonly used to treat vertigo, stomachache, diarrhea and other syndromes. The highest frequently used drugs were Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Parched Semen Ziziphi Spinosae, and Caulis Polygoni Multiflori. The most frequently used drug combinations were “Pericarpium Citri Reticulatae, Poria”, “Radix Salviae Miltiorrhizae, Poria”, and“Poria, Parched Semen Ziziphi Spinosae”. The drug association rules that the confidence coefficient was more than 0.9 were “Carina→Oyster”, “Poria, Carina→Oyster”,“Oyster, Caulis Polygoni Multiflori→Carina”, and“Rhizoma Atractylodis Macrocephalae→Poria”. Conclusion The drugs in the prescriptions containing Poria that built by Pro. Yan mostly had the effects of regulating the flow of qi, relieving uneasiness of body and mind, and cooling the blood, which reflected the clearly thought when Pro. Yan made the prescriptions.
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Objective To systematically evaluate the clinical efficacy and safety of Fufang-Danshen Injection (FD) in the treatment of unstable angina pectoris(UAP). Methods Randomized controlled trials (RCTs) and quasi-RCTs regarding FD in the treatment of UAP were collected through comprehensive searches of China National Knowledge Infrastructure(CNKI), Chinese Scientific Journals Database(VIP), Wan fang Database, Chinese Biomedical Literature Database(CBM), PubMed, Embase and Cochrane Library from January 1979 to December 2013. Two reviewers independently assessed the quality of the included studies by the Cochrane risk of bias, and extracted the information from the included studies. Meta-analysis was conducted with the software Review Manager 5.2. Results A total of 13 studies with 1156 participants were included. In the meta-analysis, ①the total effective rate of UAP:in term of FD+conventional therapy with western medicine(WM)vsWM, the difference between two groups was statistically significant [RR=1.32, 95%CI(1.21, 1.43), P<0.01]; FD+low molecular weight heparin+WM vs WM, difference between two groups was also statistically significant [RR=1.29, 95% CI(1.17, 1.42), P<0.01], which indicated that the efficacy of experimental group was higher than the control group. Other interventions, such as FD+WM vs low molecular weight heparin+WM and FD vs WM, there was no significant difference between two groups. ②the total effective rate of ECG:in term of FD+WM vs WM, the difference between two groups was statistically significant [RR=1.34, 95%CI (1.14, 1.57), P<0.01]; in term of FD vs WM, difference between two groups was statistically significant [RR=1.49, 95%CI(1.13, 1.96), P<0.01], which indicated that experimental group can effectively improve the total effective rate of ECG. ③ frequency of angina attacks:in term of FD+WM vs WM, the difference between two groups was statistically significant [MD=1.07, 95%CI(0.48, 1.66), P<0.01]. No differences between groups existed in other analysis. ④ adverse drug reactions(ADRs):4 articles cleared that there was no ADRs in the studies, 4 studies reported ADRs, which represented headache, nausea, flushing and so on. There were 9 cases in the experimental group, and 9 in control group. Conclusion Based on the meta-analysis, FD was effective and relatively safe for the treatment of UAP in clinical. However, since the articles enrolled in the study were not in high quality, more qualified studies should be conducted for the further assessment of efficacy and safety of FD for UAP.
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Objective To explore the rules of the compatible application of antagonistic combination Ginger and Radix Scutellariae in clinical.Methods The prescriptions included the compatibility application of Ginger and Radix Scutellariae were systematically retrieved in literature. Using Excellas a storage and analysis tool, the information about treatments, dosage, compatibility proportion, and dosage form were analyzed with the method of bibliometrics.Results The prescriptions included the compatibility application of “Ginger and Radix Scutellariae” were mainly used for the treatment of internal diseases (746 cases, 76%), followed by gynecological diseases (62 cases, 6%), ear-nose-throat diseases (43 cases, 4%), etc. The largest number of internal diseases was spleen-stomach diseases, which accounted for 26% (193 cases) of the total internal diseases. And the others were diseases of liver-gallbladder 189 cases (25%), and diseases of lung (185 cases, 25%). In the prescriptions, the dosages of Radix Scutellariae were primarily 10, 12, 9, 15 g, 69% (532/772) of which were in the dose range provided by Chinese Pharmacopoeia. The dosages of Ginger were mainly 10 g and 6 g, 84% (356/424) of which were in the dose range provided by Chinese Pharmacopoeia. The compatibility proportion of Ginger and Radix Scutellariae was mostly 1∶1, which accounted for 32%.Conclusion The antagonistic combination Ginger and Radix Scutellariae was widely used in a variety of interior, exterior, gynaecology, paediatrics and other syndromes. The two drugs were contrary in the property (one cold and the other hot) and the function (one warming lung and the other clearing away the lung-heat), but their compatibility application can achieve a satisfactory efficacy.