ABSTRACT
Objective:To observe the effect of enriched rehabilitation on dual-task gait disorder after a transient ischemic attack (TIA) and explore its mechanism.Methods:Sixty TIA patients were randomly divided into a control group and an observation group, each of 30. Another 30 healthy counterparts were selected to form a healthy control group. All of the TIA patients were given routine medication to lower blood pressure and improve brain function, while the observation group was additionally provided with enriched rehabilitation training for 12 weeks. Before and after the intervention, the gait and cognitive functioning of all of the subjects were quantified and their event-related potentials (P300s) and serum brain-derived neurotrophic factor (BDNF) levels were also measured.Results:Before the treatment there were significant differences between the TIA groups and healthy controls in all of the measurements, but there were no significant differences between the control and observation groups. After the treatment, no significant improvement was observed in any of the control group′s results, but there was significant improvement in the observation group′s gait parameters, cognitive functioning, average serum BDNF concentration and in the average latency and amplitude of its P300 signals.Conclusions:Enriched rehabilitation can improve the gait of TIA patients, perhaps through increasing their serum BDNF concentration and improving their cognition.
ABSTRACT
Objective:To investigate the prevalence of drinking-tea fluorosis from 2016 to 2018 in Lhasa City, Tibet, and to provide clues and basic data for preventing this disease.Methods:According to the stratified cluster sampling method, Mozhugongka County and Nimu County in 2016, Dazi District in 2017, Chengguan District, Duilongdeqing District and Qushui County of Lhasa City in 2018 were selected as survey counties (districts), each county (district) selected 1 township (town) according to the 5 directions of east, south, west, north, and middle, and each township (town) selected 1 to 2 administrative villages as survey points, and each survey point recruited villager volunteers aged ≥18 years for survey subject. All volunteers were tested for dental fluorosis (Dean method) and skeletal fluorosis (X-ray), and samples of drinking water, brick tea consumed at home and residents' urine were collected for water fluoride, tea fluoride, and urine fluoride testing.Results:A total of 30 water samples were collected, and the water fluoride content was all < 1.0 mg/L. The average fluorine content was 1 167.5 mg/kg among 314 samples of brick tea investigated in this study. The qualification rate of brick tea in each survey county was 0 - 16.7%. The daily intake of fluoride in brick tea per person was 6.4 mg. The prevalence of dental fluorosis was 18.1% (350/1 929) among all enrolled participants, 4 of the 6 survey counties (districts) had varying degrees of dental fluorosis. A total of 1 637 urine samples were collected and detected, and the urine fluorine level ranged from 0.01 to 11.01 mg/L, with a geometric mean of 1.07 mg/L. The urine fluorine levels in all investigated counties (districts) were under the standard limits (≤1.6 mg/L). Eight adults were diagnosed with skeletal fluorosis of degree Ⅰ via X-ray detection, with a detection rate of 0.4% (8/1 929). Totally 20.2% (390/1 929) of people reported suffered from two or more joint disease. Furthermore, 6 counties (districts) in Lhasa City were identified as mild drinking-tea type endemic fluorosis disease areas.Conclusion:From 2016 to 2018, the fluorine content of brick tea in Lhasa has exceeded the standard seriously, dental fluorosis is mildly prevalent in some counties (districts), and 6 counties (districts) are all mild tea-drinking fluorosis areas.