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Objective To analyze type of irrational outpatient infusion prescriptions returned by clinical pharmacists'pre -prescription review and intervention in our hospital.Methods Outpatient infusion prescriptions reviewed by clinical pharmacists in 2014 were statistically analyzed in terms of type,constitution and rate of qualified prescriptions.Results Type of unstandard writing or input errors prescriptions accounted for 35.19%,which was the great majority of the irrational outpatient infusion prescriptions.The rate of qualified prescriptions was 99.15%,which was higher than 91.53% in 2011 when pre -prescription review and intervention had not implemented.Conclusion Pre -prescription review and intervention could improve the quality of outpatient infusion prescriptions.Finally,safety and effectiveness of outpatient infusion could be guaranteed.
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Objective To investigate the relationship between adiponectin /leptin ratio and metabolic index in type 2 diabetes mellitus .Methods A total of 167 cases of type 2 diabetes in our hospital endocrinology clinic 59 people from January 2013 to 2014 were enrolled in the study ,all patients were divided into three groups accordius to fasting plasma glucose(FPG)(42 people 9 .4mmol/L as Group 3) .Patients who have been excluded from treatment with insulin or insulin .Requiring patients to 10 - 12 hours of fasting ,taken fasting blood samples and samples will be sent to the hospital clinical laboratory measured by biochemical analysis way ,the patient of glycosylated hemoglobin ,fasting blood glucose ,blood lipid indexes for comprehensive testing and calculation of patient related indexes ,and carries on the analysis .Results the patient′s body mass index(BMI) ,fasting insulin (FINS) ,low‐density lipoprotein cholesterol(LDL) ,triglyceride(TG) ,leptin and adiponectin ,between the ages of no statistical significance exists ,male patients with adiponectin levels and TG ,BMI ,HDL and LDL has a relatively close relationship (positive ,P=0 .000 3) leptin levels and BMI was negatively correlated (P<0 .05) .The adi‐ponectin levels of female patients were closely related to TG ,LDL and HD (positive correlation ,P<0 .05) .Leptin levels and TG were associated with BMI (negative correlation) ,and A/L ratio was correlated with all the indexes (negative correlation) in male and female patients (P<0 .05) .Conclusion HOMA‐IR can not be used as an important indicator of insulin resistance ..A/L and it are more suitable for .
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Objective Analyse and report the diagnosis and treatment process of vulvar epithelioid sarcoma, it provides a basis for rare case in clinic. [Methods] Through the analysis of the patient's il ness, treatment, and pathology examination, and the effect of the treatment of prognosis of vulvar epithelioid sarcoma of the summary, truly record the occurrence of vulvar epithelioid sarcoma development, treatment and prognosis. [Results] The intraoperative pathologic examination in patients diagnosed the vulvar epithelioid sarcoma, and it used the removal of expanding. Now the patient is not recurred. [Conclusion] Vulvar epithelioid sarcoma is clinical y rare, needs combined with immunohistochemical examination at the time of diagnosis, removal of local expansion is the effective method to treat, it is not exactly curative effect of chemotherapy and radiotherapy.
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Objective To investigate the effects of carboxymethytl pachymaram ( CMP ) on the methylation of SOCS-1 (suppressor of cytokine signaling-1) gene and the in vitro maturation of human mono-cyte-derived dendritic cells (DCs).Methods Human DCs were induced from the peripheral blood mono-cytes in vitro with the treatment of recombined human GM-CSF and interleukin-4 ( IL-4 ) and cultured with different concentrations of CMP (10, 50, and 100 mg/L).The methylation and expression of SOCS-1 gene were analyzed by methylation-specific polymerase chain reaction (MSP) and real-time PCR, respectively. The phenotypic markers of DCs were detected by flow cytometry .Mixed lymphocyte reaction ( MLR) and ELISA were performed to measure the lymphocyte proliferation induced by DCs and IL-12 secretion by DCs . Results CMP promoted the methylation of SOCS-1 gene, but inhibited the expression of SOCS-1 gene in dendritic cells at the concentrations of 50 mg/L and 100 mg/L.The expression of phenotypic markers (CD80, CD83, CD86 and HLA-DR), IL-12 secretion and lymphocyte proliferation induced by DCs were significantly enhanced in a dose dependent manner with the treatment of CMP .Compared with control group , the levels of methylated SOCS-1 gene and IL-12 and the lymphocyte proliferation index were increased upon the stimulation with 50 mg/L and 100 mg/L of CMP (P<0.01), but the expression of SOCS-1 gene was de-creased.The expression of CD80, CD83 and HLA-DR on DCs in the presence of 100 mg/L of CMP were higher than those of control group (P<0.05).Conclusion CMP could induce the methylation of SOCS-1 gene and the maturation of DCs derived from peripheral blood monocytes .