ABSTRACT
Objective:To investigate the characteristics and associated factors of depression in elderly patients with Parkinson's disease(PD).Methods:A total of 1138 elderly PD patients from Xuanwu Hospital of Capital Medical University were consecutively enrolled.The Hamilton Depression 17-item Scale(HAMD-17)was used to diagnose depression(scores ≥14). The depressive characteristics of PD patients with depression and those without depression were compared, and Logistic regression model was used to analyze the clinical risk factors of depression in PD patients.Results:Among the 1 138 PD patients, 233 cases had depression.The incidence of depression in PD patients was 20.5%, and the treatment rate was only 6.0%(14 cases). The main symptoms of depression in PD patients included sleep disturbance(101 cases, 43.3%), depression(57 cases, 24.5%), work and interest loss(49 cases, 21%). Compared to PD patients without depression, PD patients with depression were more likely women(49.4% vs36.3%), and had lower cognitive scores[(25.56 ± 4.22)scores vs(27.07 ± 3.08)scores], higher rate of freezing of gait(51.0% vs24.0%), higher incidence of disability(87.1% vs28.5%)( P<0.05). A comparison of each part of the unified Parkinson's disease rating scale(UPDRS)between the two groups revealed that the scores of activities of daily living[(16.52 ± 8.71)scores vs(10.15 ± 5.48)scores], the motor examination[(33.78 ± 19.48)scores vs(22.87 ±13.08)scores]and the complications of therapy[2.0(0.0, 6.0)scores vs0.0(0.0, 2.0)scores]were higher in the PD patients with depression group than in the PD patients without depression group( P<0.05). Logistic regression analysis showed that women( OR=1.532, 95% CI: 1.073-2.187, P=0.019), disability( OR=6.357, 95% CI: 4.399-9.186, P<0.001), activities of daily living evaluated by UPDRS( OR=1.093, 95% CI: 1.043-1.146, P<0.001)and motor complications( OR=1.100, 95% CI: 1.014-1.193, P=0.022)were independent risk factors for PD depression. Conclusions:Depression was common in PD patients and usually manifested as sleep disturbance and low motivation, women, motor complications, disability and decreased quality of daily living were independent risk factors for depression.
ABSTRACT
Objective To investigate the relationship between serum uric acid (UA)levels and Parkinson's disease (PD) risk under specific lifestyle exposures.Methods Case-control study was used.Three hundred and ninety-seven PD cases and the same number of controls with matched age and gender were selected.Demographic and exposure information was collected by face-to-face interview,and blood biochemistry studies tested.Logistic regression model was used to analyze the association of PD risk with UA levels or enviromental factors.Results The highest value of UA levels was associated with a decreased PD risk compared to the lowest value (OR =0.39,95％ CI 0.25-0.63) in both male and female groups.This association was significant among nonsmokers (OR =0.52,95％ CI 0.32-0.76),nondrinkers (OR =0.4,95％ CI 0.34-0.70),and persons taking exercise more than 1 houre a day (OR =0.51,95％ CI 0.35-0.74).But no significant association was affected in the subjects with smoking or drinking history and those with less exercise (＜ 1 hour a day).Conclusion We confirmed that higher UA levels were associated with lower PD risk in Chinese population,and some lifestyles may modify the protection effect of serum UA.