ABSTRACT
Objective:To explore the influencing factors of neutrophil to lymphocyte ratio (NLR) in patients with chronic heart failure (CHF) and the relationship between NLR and cardiac contractile function.Methods:From September 2016 to May 2018, 135 CHF patients were enrolled in the cardiovascular department of Fenyang hospital, Shanxi Province for prospective research.According to the level of NLR, the patients were divided into three groups: low NLR group (<2.3, 46 cases), middle NLR group (≥2.3~≤4.3, 45 cases), high NLR group (>4.3, 44 cases). The basic clinical data, laboratory examination data and noninvasive cardiac hemodynamic indexes of the three groups were compared.Results:(1) By comparing the data of different NLR groups, we found that there were significant differences in (N-terminal pro-brain natriuretic pepfide, NT-proBNP)( F=4.485, P=0.013), total bilirubin( F=6.085, P=0.003), albumin( F=3.695, P=0.027). (2)NLR was correlated with NT proBNP, total bilirubin, albumin( r=0.267, 0.256, -0.243, P=0.002, 0.003, 0.005, respectively). (3)Multiple linear regression analysis showed that NLR of CHF patients was correlated with left ventricular ejection fraction (LVEF), NT proBNP, total bilirubin and albumin (standard regression coefficients were -0.239, 0.223, 0.247 and -0.213, respectively, P<0.05). (4) Pearson correlation analysis showed that NLR and cardiac output ( r=-0.173, P=0.045), cardiac index ( r=-0.175, P=0.042), LVEF ( r=-0.278, P=0.001), maximum ejection velocity ( r=-0.207, P=0.016), systolic index ( r=-0.214, P=0.013), hearther index(HI) ( r=-0.179, P=0.038), cardiac work (CW) ( r=-0.235, P=0.006), cardiac workindex (CWI)=( r=-0.244, P=0.004) were negatively correlated. Conclusion:NT-proBNP, total bilirubin, albumin and LVEF are the factors that affect the NLR of patients with CHF.NLR has a certain value in the evaluation of CHF, therapeutic effect and prognosis prediction.
ABSTRACT
Objective To explore the relationship of adiponectin and brachial ankle pulse wave velocity (baPWV) in type 2 diabetes mellitus patients combined with hypertension.Methods Fifty-six patients with diabetes mellitus,69 diabetes mellitus patients combined with hypertension and 78 healthy people were recruited in our study who visited doctors in Fenyang Hospital from March 2010 to March 2012.The levels of adiponectin,brachial ankle pulse wave velocity and other biochemical indicator were determined.Analyzed the correlation between adiponectin and baPWV among the three groups.Results The levels of adiponectin in control group,diabetes mellitus group,and diabetes mellitus combined with hypertension group were (13.9 ±4.2) mg/L,(9.1 ± 3.8) mg/L and (7.6 ± 2.4) mg/L respectively,and the difference was statistically significant (F =62.53,P ＜0.01).The levels of baPWV in control group,diabetes mellitus group and diabetes mellitus combined with hypertension group were (1 617.4 ± 198.2) cm/s,(2 010.9 ±231.7) cm/s and (2 196.1 ±218.6) cm/s respectively,and the difference was also statistically significant (F =139.41,P ＜ 0.01).The correlation between adiponectin level and baPWV among three groups were-0.629,-0.561,and-0.528,respectively (P =0.027,0.034,0.029).Conclusion The levels of adiponectin decreased in diabetes mellitus patients combined with hypertension,while the baPWV increased.There is a good correlation between adiponectin and baPWV.