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Objective To analyze and compare the mental health service resources in Jiangsu Province in 2014 and 2020, and to provide suggestions for the rational allocation and setting of mental health resources. Methods The national mental health resource questionnaire compiled by National Health Commission and the information system of Jiangsu provincial severe mental disorders were used to investigate the number, beds, mental health personnel of mental health institutions, and to evaluate the management and service situation of patients with severe mental disorders in Jiangsu Province in 2014 and 2020. The data was analyzed by SPSS 19.0 software. Results Compared with the mental health service resources in 2014, the number of mental health medical institutions increased by 9 in 2020; The number of psychiatric beds increased by 5,936, and the growth rate was 39.55%; The number of psychiatric open beds increased by 5,311, and the growth rate was 27.41%. The bed density increased from 2.43 beds / 10,000 people to 3.08 beds / 10,000 people, with an increase rate of 26.75%. The number of mental health practitioners increased from 8.08/100,000 to 12.27/100,000. In 2020, 37.28% of the hospitals of the second class and above set up psychiatric or psychological clinics in Jiangsu Province. In terms of management services for patients with severe mental disorders, the prevalence rate in 2020 was 0.43%, higher than 0.34% in 2014 (χ2=8441.60, P＜0.05), and the management rate in 2020 was 95.22%, higher than 90.97% in 2014 (χ2=5520.13, P＜0.05). The drug taking rate in 2020 was 81.22%, higher than 57.18% in 2014 (χ2=37254.45, P＜0.05), and all the differences were statistically significant. Conclusion The resources of mental health services in Jiangsu Province have increased, but the number of medical personnel cannot meet the requirements of regional development, and the distribution of mental health resources is unbalanced. It is necessary to reasonably distribute resources and strengthen the training of mental health practitioners.
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Objective To assess whether topiramate prevents body weight gain in patients with olanzapine .Methods The ran‐domized controlled trials(RCTs) about topiramate for prevention of weight gain with olanzapine from 1998 to 2013 were searched in the Cochrane Library ,Pubmed ,EMbase ,WanFang Data ,CNKI and VIP .Two reviewers independently screened the literatures ,ex‐tracted the data ,and evaluated the methodological quality .Then Meta‐analyses were conducted by using RevMan 5 .1 software .Re‐sults The total of 11 RCTs were included .Among the 549 patients were involved .The results of Meta‐analyses showed that the ef‐ficacy of the topiramate group was superior to that of the control group in lessen body mass with significant difference (MD= -3 .68 ,95% CI:-5 .16- -2 .19 ,Z=4 .86 ,P<0 .01) .Conclusion Topiramate addition therapy is effective in attenuating olanzapine‐induced weight gain .
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Purpose The aim is to study the pharmacokinetic of iv thymopeptide in rabbit.Method Thymopeptide concentration of rabbit plasma was determined by HPLC and pharmacokinetic parameters were computerized with 3P87 program.Results and Conclusions The pharmacokinetic parameters of iv thymopeptide in rabbit were:Cmax=(30.06±9.27)μg/ml,t1/2(β)=(29.24±23.78)min, Ke=(0.032 3±0.013 8)min-1 and AUC 0→∞=(205.63±46.48)μg*min/ml.