Prevalence and influencing factors of respiratory symptoms among people aged 40 years and above in China / 中华流行病学杂志

Objective To investigate the prevalence and influencing factors on respiratory disease related symptoms (coughing,expectoration,persistent coughing and persistent expectoration) in Chinese people ≥40 years old.Methods Data was collected from 162 surveillance points in the China Non-communicable and Chronic Disease Surveillance Project in 2010.A total number of 56 066 people,aged ≥40 years,were selected by multi-stage cluster random sampling method in this study.The prevalence rates of coughing,expectoration,persistent coughing and persistent expectoration were calculated according to gender by x2 test.Multivariate logistic regression model was used to analyze the related influencing factors.Results The prevalence rates of coughing,persistent coughing,expectoration and persistent expectoration in men were significantly higher than that in women (P＜ 0.01).The prevalence rate of respiratory symptoms was positively correlated with age and duration and amount of cigarette smoking (P＜0.01),while negatively correlated with participants' education level (P＜0.01).Results from multivariate logistic regression analysis showed that gender,age,education level,smoking-related parameters,areas of residency (in urban or rural areas),etc.were appeared as influencing factors on the prevalence of respiratory symptoms.Conclusion The symptoms of chronic respiratory diseases appeared prevalent in Chinese population aged ≥40 years.Factors as older age,living in the central/western regions and smoking-related parameters were identified as of higher risks.

Prevalence and influencing factors of respiratory symptoms among people aged 40 years and above in China / 中华流行病学杂志

Objective To investigate the prevalence and influencing factors on respiratory disease related symptoms (coughing,expectoration,persistent coughing and persistent expectoration) in Chinese people ≥40 years old.Methods Data was collected from 162 surveillance points in the China Non-communicable and Chronic Disease Surveillance Project in 2010.A total number of 56 066 people,aged ≥40 years,were selected by multi-stage cluster random sampling method in this study.The prevalence rates of coughing,expectoration,persistent coughing and persistent expectoration were calculated according to gender by x2 test.Multivariate logistic regression model was used to analyze the related influencing factors.Results The prevalence rates of coughing,persistent coughing,expectoration and persistent expectoration in men were significantly higher than that in women (P＜ 0.01).The prevalence rate of respiratory symptoms was positively correlated with age and duration and amount of cigarette smoking (P＜0.01),while negatively correlated with participants' education level (P＜0.01).Results from multivariate logistic regression analysis showed that gender,age,education level,smoking-related parameters,areas of residency (in urban or rural areas),etc.were appeared as influencing factors on the prevalence of respiratory symptoms.Conclusion The symptoms of chronic respiratory diseases appeared prevalent in Chinese population aged ≥40 years.Factors as older age,living in the central/western regions and smoking-related parameters were identified as of higher risks.

Ambient PM2.5 during pregnancy and risk on preterm birth / 中华流行病学杂志

<p><b>OBJECTIVE</b>To investigate the association between ambient fine particulate matter with aerodynamic diameter less than 2.5 μm (PM2.5) and the risk on preterm birth.</p><p><b>METHODS</b>A total of 1 882 pregnant women with local residency of Taiyuan city and underwent delivery at the First Hospital of Shanxi Medical University with the dates of conception between January 1 and December 31, 2013, were enrolled in the study. Information on general demographics, home address and history on pregnancy, lifestyle and related environmental factors were collected through in-person interview. Birth outcomes and maternal complications were abstracted from medical records. Data on the amount of daily average PM2.5 from 8 monitor points in Taiyuan city, between March 1, 2012 and December 31, 2013 were also collected. Individual exposure during pregnancy were calculated using the inverse-distance weighting method, based on home address. Multivariate unconditional logistic regression model was used to examine the associations among PM2.5 exposure, risk of preterm birth and related clinical subtypes.</p><p><b>RESULTS</b>The overall incidence of preterm birth was 8.21% (151/1 839)in 1 839 pregnant women. Exposure to ambient PM2.5 during the second week prior to delivery was associated with an increased risk of preterm birth (OR=1.087, 95% CI: 1.001-1.182 per 10 μg/m(3) increase) and mild preterm birth (OR=1.099, 95% CI: 1.007-1.200 per 10 μg/m(3)). Compared to data from the China Environmental Air Quality Standard, higher level of exposure (≥75 μg/m(3)) of PM2.5 during the second week before delivery was associated with an increased risk of preterm birth (OR=1.008, 95%CI: 1.000-1.017) but the association was mainly seen for mild preterm birth (OR=1.010, 95%CI: 1.001-1.018).</p><p><b>CONCLUSIONS</b>RESULTS from our study showed that exposure to high level of PM2.5 during late pregnancy would increase the risk of preterm birth. Future large studies are needed to examine the association by preterm clinical subtypes and to elucidate potential underlying mechanisms.</p>

EXPRESSIONS OF IL-1? AND IL-1RI mRNA IN THE RAT CAROTID BODY / 解剖学报

Objective To study the expressions of IL-1 receptor type Ⅰ(IL-1RI) mRNA and IL-1? protein in the rat carotid body. Methods In situ hybridization,immunofluorescence double staining and Western blotting methods were used. Results The result of in situ hybridization showed that the positive signal of IL-1? mRNA was mainly located in the glomus cells of the carotid body.The result of immunofluorescence double staining showed that IL-1? protein also expressed in the glomus cells of the organ.The Western blotting proved that the IL-1? immunoreactive band appeared at 18kD,consistent with the molecular weight of the cytokine.Conclusion The glomus cells of the rat carotid body not only express IL-1RI mRNA,but also IL-1?.

Human Exposure Factors in Health Risk Assessment / 环境与健康杂志

Human exposure factor is one of the important parameters in environmental health risk assessment models. Proper selection of the exposure factors will contribute significantly to improve the accuracy of health risk assessment. This paper reviewed recent application of some key exposure factors for environmental health risk assessment in the USA, EU, Japan, etc. Some suggestions were proposed on focuses and trends of the related research in near future in China, based on the further analysis for the exposure factors of Chinese population.