ABSTRACT
Objective:To evaluate dynamic changes of functional status in elderly emergency inpatients by using the interRAI Acute Care for Comprehensive Geriatric Assessment(interRAI AC-CGA), and to analyze whether assessment results are helpful for clinical decision-making.Methods:Elderly patients(aged 60 years and older)who were hospitalized in the Acute Care Unit of PLA General Hospital from October 2017 to March 2018 were included.Each patient received the interRAI AC-CGA instrument-based assessment at admission(day 1), on day 7 and day 28 after admission.Analysis of collected data was conducted using interRAI AC-CGA scales, geriatric syndrome screening and risk identification of adverse outcomes, in order to examine dynamic changes of functional status in patients at and after admission and to explore the relationship between functional status at admission and outcomes(at discharge).Results:Thirty-four patients were evaluated, including 26 males and 8 females, aged from 60 to 101 years, with a mean age of(84.2±10.1)years.Patients had a variety of functional abnormalities at admission and during hospitalization, in which the ability to perform activities of daily living(ADL)and instrumental activities of daily living(IADL)decreased significantly.Compared with evaluation results on day 1, the incidences of functional abnormalities on day 7 and day 28 declined, and there was improvement in transient depression, pain and falls( χ2=6.298, 6.027 and 7.766, P=0.043, 0.049 and 0.021). After evaluation on day 28, 16 patients were discharged and 18 remained hospitalized(including 2 deaths). The rate for most abnormality was lower in the discharge group than in the continued hospitalization group, and the rates for abnormal communication and falls were lower in the discharge group than in the continued hospitalization group( χ2=6.349 and 5.443, P=0.019 and 0.030). Age(≥85 years old)had no effect on discharge.There was no significant difference in hospital discharge rate between the advanced age group(≥85 years old)and the elderly group(60-84 years old)(40.0% or 8/20 vs.57.1% or 8/14, χ2=0.971, P=0.324). Conclusions:The interRAI AC-CGA instrument can systematically and dynamically estimate functional changes in elderly emergency inpatients.Functional status at admission is related to prognosis(performance at discharge)of patients.
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The aim of this experiment is to find a feasible impersonal index for analyzing the physiological mental fatigue level. Three characteristic parameters, relative power in different rhythm, barycenter frequency and power spectral entropy, are extracted from two channels' electroencephalogram (EEG) under two physiological mental fatigue states. Then relationships between such three parameters and physiological mental fatigue are analyzed to explore whether they can be of use for detecting (or monitoring) the mental fatigue level. The experiment results show that the relative power, barycenter frequency and power spectral entropy of EEG exhibit strong correlation with physiological mental fatigue level. While physiological mental fatigue level increases, the relative power in theta, alpha and beta rhythms, barycenter frequency and power spectral entropy of EEG decrease, but the relative power in delta rhythm of EEG increases. The relative power in four rhythms, barycenter frequency and power spectral entropy of EEG reflect the change of physiological mental fatigue level sensitively, and may hopefully be used as indexes for detecting physiological mental fatigue level.
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Adult , Humans , Male , Young Adult , Electroencephalography , Entropy , Mental Fatigue , Signal Processing, Computer-AssistedABSTRACT
The event-related desynchronization/synchronization(ERD/ERS) time courses of lower and upper alpha band rhythms during hand motor imagery are investigated respectively by Fourier Sectral Entropy (FSE) in this paper. By analyzing one group of BCI competition data, it was found that FSE within upper alpha band displays a pronounced increase and decrease over contralateral and ipsilaterai brain areas respectively at the onset of hand motor imagery, which is corresponding to the antagonistic ERD/ERS patterns in previous studies. Different from the upper alpha activity pattern, FSE within lower alpha band displays a consistent increase over both two hemispheres hand representative areas. The preliminary results show that FSE could disclose the different behaviors of the upper and lower alpha band rhythms so that a new idea with the complexity measure is provided to characterize functional dissociation of lower and upper frequency alpha rhythms in relation to hand motor imagery.
ABSTRACT
The event-related desynchronization/synchronization(ERD/ERS) time courses of lower and upper alpha band rhythms during hand motor imagery are investigated respectively by Fourier Sectral Entropy (FSE) in this paper. By analyzing one group of BCI competition data, it was found that FSE within upper alpha band displays a pronounced increase and decrease over contralateral and ipsilateral brain areas respectively at the onset of hand motor imagery, which is corresponding to the antagonistic ERD/ ERS patterns in previous studies. Different from the upper alpha activity pattern, FSE within lower alpha band displays a consistent increase over both two hemispheres hand representative areas. The preliminary results show that FSE could disclose the different behaviors of the upper and lower alpha band rhythms so that a new idea with the complexity measure is provided to characterize functional dissociation of lower and upper frequency alpha rhythms in relation to hand motor imagery.
ABSTRACT
Objective To investigate the effects of rhubarb extracts, i.e. rhein and emodin, on the neuronal hyperexcitability and synaptic transmission, and to further reveal the mechanism of the secondary brain damage. Methods The fluid percussion injury (FPI) rat model and extracellular recording method were used. The evoked field potentials by stimulating Schaffer collaterals were collected from the ipsilateral (impact side) and the contralateral hippocampal CA1 areas of rat in vitro. And the field potentials, including the field excitatory postsynaptic potential and the population spike, were analyzed. Results After the impact was performed on the rat parietal cortex, the evoked field potentials in the ipsilateral hippocampus CA1 area were enhanced obviously. Rhubarb extracts reduced the slope of the field excitatory postsynaptic potential and the number of the population spike significantly while rhein and emodin increased the latency of the population spike obviously. Conclusion Rhubarb extracts, i.e. rhein and emodin, can depress the neuronal hyperexcitability, which suggests that rhein and emodin play an important role in protecting the central nervous system from neuronal damage after traumatic brain injury. FPI produces hyperexcitability of hippocampal CA1 neurons, probably by enhancing excitatory synaptic transmission.