ABSTRACT
Objective:To evaluate the feasibility of fine-needle aspiration cytology (FNAC) in diagnosing vascular abnormality in oral and maxillofacial region.Methods: The method of retrospective study was used.The data from the patients who underwent FNAC from 2011 to 2014 in Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology were collected.All the included patients were divided into surgery group and non-surgery group.The patients in surgery group underwent lesion resection and the postoperative pathological results were gained.The patients in non-surgery group underwent periodical sclerotherapy.The accuracy of FNAC was identified by histopathologic diagnosis in surgery group and the effect of sclerotherapy in non-surgery group.Results: In this study, 93 patients were involved, including 51 males and 42 females.The median age was 2.5 years.Among them, 67 cases were judged as vascular abnormality by FNAC, and 63 cases were in consistent with final diagnosis and 4 cases were not.Among the other 26 cases which were diagnosed as other diseases by FNAC, 5 cases were accorded with final diagnosis.Therefore, the sensitivity of FNAC on diagnosis of vascular abnormity was 93% and its specificity was 84%.Among them, there were 29 cases in the surgery group and 64 cases in the non-surgery group.FNAC results were in consistent with the postoperative pathological results in 20 cases in surgery group (69%), and not consistent with pathological results in 9 cases.The pathological diagnoses included vascular malformations (3 cases), neurofibromas (2 cases), hamartoma (1 case), sebaceous cyst (1 case), adenolymphoma (1 case), and descriptive diagnosis (1 case).In non-surgery group, FNAC results were in consistent with the clinical effect of sclerotherapy in 61 cases (95%).There were 3 misdiagnosed cases.The coincident rate between the result of FNAC and that of pathological or clinical diagnosis was 86%.Conclusion: FNAC is a feasible and minimal invasive method to diagnose vascular abnormality in oral and maxillofacial region.
ABSTRACT
Fine needle aspiration cytopathology of the breast is an effective means of distinguishing malignant from benign,and the aspirated sample collections techniques is the primary and key part of fine needle aspiration.Fine needle aspiration cell block has been improved and used on preoperative breast cancer molecular portraits.This paper will provide an introduction to application of specimens collection techniques,application and development of fine needle aspiration cell block on preoperative breast cancer molecular portraits.
ABSTRACT
<p><b>OBJECTIVE</b>To study the basic morphological factors and the reliability and limitations of the diagnostic standards of fine needle aspiration cytology (FNAC) of breast masses which drafted.</p><p><b>METHODS</b>A total of 4 309 fine needle aspiration biopsy cases of breast were performed and 951 cases of which were checked with their histological diagnosis.</p><p><b>RESULTS</b>Of the 413 aspiration smear studies, relatively identical morphological features were found on the smears of lesions of the same nature. The sensitivity of diagnosis of malignant tumor in 732 cases, the specificity of diagnosis of benign lesion in 219 cases and the overall accuracy of diagnosis were 97.3%, 97.7%, and 97.4% respectively. The false negative rate, potential false positive rate and the overall misdiagnosis rate were 2.7%, 2.3% and 2.6% respectively, no false positive diagnosis case was found.</p><p><b>CONCLUSIONS</b>(1) The differentiation and the arrangement pattern of the tubular epithelial cells and the amount of benign naked nuclear cells are the three essential factors in the analysis of morphological changes of FNAC of breast mass. (2) The examination of our diagnostic standards of FNAC of breast masses shows that the standards are very reliable but have certain limitations which need to be resolved by histopathological diagnosis.</p>