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OBJECTIVE:To investigate the features of adverse drug reactions(ADR) occurred in the infusion room of our hospital so as to improve rational clinical drug use.METHODS:A total of 225 ADR cases reported by the infusion room of our hospital from Jan.1,2007 to Dec.31,2008 were analyzed retrospectively and statistically.RESULTS:Of the total 225 ADR cases reported,109 cases(48.44%) were children aged below 10;115 cases(51.11%) occurred within 10～30 min;ADR were induced by 29 kinds of medicines,with cephalosporin and penicillins showing the highest proportions(43.56% and 23.56%,respectively);143 cases(63.6%) manifested more often as lesions of skin and its appendage followed by ADR of digestive system(40 cases/17.8%).CONCLUSION:ADR monitoring plays an important role in medical institution.Tightening ADR monitoring in the infusion room contributes to patients' medication safety.
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OBJECTIVE: To discuss the establishment of standard and practical inpatient medication history.METHODS: The standard inpatient medication history in our hospital which has been established by clinical pharmacists during ward rounds participation consists of four parts: first page of medication history,relevant medical checking-up records,therapeutic drug records and discharge summary.RESULTS & CONCLUSION: The standard medication history has contributed to the rational use of drugs,meanwhile,it is a concrete manifestatation of standard pharmaceutical care provided by clinical pharmacists.
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OBJECTIVE:To study the effect of irbesartan and losartan on pharmacokinetics of cyclosporin A(CsA)in rabbits. METHODS: 12 rabbits were randomly divided into two groups(n=6). In self-controlled study,plasma concentration of CsA in rabbits of two groups before and after treating with combination of irbesartan and losartan were determined and pharmacokinetics parameters were examined. RESULTS: After combination of irbesartan or losartan,the Cmax and AUC0～24 of CsA were significantly increased(P
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OBJECTIVE:To prepare and establish the method for measuring the content of ornidazole gargle.METHODS:Maximal wavelength and dual-wavelength point spectrophotometries were used to determine the contents of ornidazole and chlorhexidine acetate respectively.RESULTS:The calibration curve of ornidazole and chlorhexidine acetate were linear in the range of5.5～16.6?g/ml and5.6～16.8?g/ml respectively.The average recovery rates of ornidazole and chlorhexidine acetate were100.23%and99.77%respectively,and their RSD were0.47%and0.31%respectively.CONCLUSION:The method of preparation and quality control is simple,quick and accurate.