ABSTRACT
ObjectiveTo investigate predictive value of matrix metalloproteinase-9 (MMP-9) and Interleukin-6 (IL-6) combined with cervical length in premature delivery.MethodsPlasma samples of 62 pregnant women were detected in this study.Samples were divided into three groups based on pregnancy outcomes.MMP-9 and IL-6 values were determined by ELISA.Cervical length was measured by transvagihal sonography.ResultsThe level of MMP-9 of the pregnant women in the premature delivery group was significantly higher than that of continuous pregnant group and that of normal pregnant women [(47.24 ±6.41) ng/ml,(523.24 ± 62.35) pg/ml vs (20.39 ±7.23 )ng/ml,(219.29 ± 80.23)pg/ml,(32.18 ±5.16)ng/ml,(406.18 ±71.52) pg/ml,P ＜0.01].The level of MMP-9 and IL-6 of the pregnant women in the continuous pregnant group was significantly higher than that of normal pregnant women [(32.18 ±5.16)ng/ml,(406.18 ±71.52) pg/ml vs (20.39 ±7.32) ng/ml,(219.29 ± 80.23) pg/ml,P ＜0.01].Cervical length of the pregnant women in the premature delivery group was significantly shorter than that of normal pregnant women and that of continuous pregnant group [( 15.62 ± 2.31 )mm vs ( 31.05 ± 1.48 )mm,(26.14 ±3.12)mm,P ＜0.01].ConclusionsDetection of level of MMP-9 and IL-6 combined with measurement of cervical length can be used as predicting index of premature delivery.