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To explore therapeutic effect of early hyperbaric oxygen therapy (EHOT) on acute cerebral infarc‐tion (ACI) patients and its influence on neurological function ,blood oxygen saturation and serum levels of macrophagocyte colony stimulating factor (M‐CSF) ,oxidized low density lipoprotein (ox‐LDL) and soluble intercellular adhesion molecule (sICAM)‐1. Methods :The 100 ACI patients treated in our hospital from Mar 2017 to Dec 2017 were randomly and equal‐ly divided into routine treatment group and HOT group (received EHOT based on routine treatment ) ,both groups were treated for 14 d.Score of United States National Institutes of Health Stroke Score (NIHSS) ,blood glucose ,blood oxygen saturation ,serum levels of lactic acid ,M‐CSF ,ox‐LDL and sICAM‐1 were observed and compared between two groups be‐fore and after treatment .Results :As time went on ,NIHSS score significantly reduced in two groups ,P＜0.05 or ＜0.01. On 7d ,14d and 21d after treatment ,NIHSS score of HOT group was significantly lower than that of routine treatment group , P＜0.05 or ＜0.01. Compared with routine treatment group after treatment ,there was significant rise in blood ox‐ygen saturation [ (83.54 ± 13.87)% vs.(99.29 ± 14.62)%] ,and significant reductions in levels of blood glucose [ (5.89 ± 2.36) mmol／L vs.(4.75 ± 2.84) mmol／L] ,serum lactic acid [ (5.53 ± 2.63) mmol／L vs.(3.75 ± 2.38) mmol／L] , M‐CSF [ (764.57 ± 10.39) μg／L vs.(634.56 ± 189.54) μg／L] ,ox‐LDL [ (346.65 ± 78.63) μg／L vs.(249.53 ± 74.32) μg／L] and sICAM‐1 [(683.87 ± 168.76) μg／L vs.(543.76 ± 147.84) μg／L] in HOT group ,P＜0.05 or ＜0.01. Conclu‐sion :Early hyperbaric oxygen therapy can significantly improve neurological function and blood oxygen saturation ,reduce serum levels of M‐CSF ,ox‐LDL and sICAM‐1.
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Objective To study the effect of mecobalamine treatment on acute cerebral infarction combined with high homocysteine (Hcy) and post-stroke depression.Methods A total of 160 cerebral infarction patients with high Hcy were collected from January 2010 to December 2011 in our hospital.Patients were randomly divided into two groups:the control group (n=80,with routine therapy) and the treatment group (n=80,with routine therapy plus intramuscular injection with folic acid 500μg for 8 weeks).The plasma concentration of Hcy was determined by fluoresene polarization immunoassay.The improvement of depression,anxiety and life skills in patients were assessed by selfmade questionnaires and self-reporting inventory (SLC 90).Results There were no significant differences in plasma Hcy level in control group before versus after treatment [(21.86±4.76) μmol/L vs.(18.67±3.81) μmol/L,t=0.40,P＞0.05].Compared with before treatment,plasma Hcy level in treatment group was significantly reduced 4 weeks after treatment [(11.66 ± 3.28) μmol/L vs.(22.68±5.16) μmol/L,t=2.55,P＜0.01].There was a significant difference in plasma Hcy level between the treatment group and the control group after treatment [(11.66 ±3.28) μmol/L vs.(18.67±3.81) μmol/L,t=7.40,P＜0.01].TheSCL-90 total score,positive symptom items score,the total score and the average score of positive symptom items were significantly lower in treatment group after treatment than in treatment group before treatment (t=2.04,2.97,5.45,4.21,all P＜0.05) and in control group after treatment (t 7.40,7.58,12.78,4.15,all P＜0.05).The improvement on symptomatic patterns including somatization,obsessive-compulsive problems,interpersonal sensitivity,depression,anxiety and fear were better in treatment group after treatment than in treatment group before treatment (t 2.34,2.28,2.51,2.19,3.40,2.35,allP＜0.05) and in control group after treatment (t=4.10,5.04,5.12,4.18,5.48,5.20,all P＜0.05).There were no significant differences in the improvement in paranoid ideation between the treatment group before and after treatment (t=1.40,P＞0.05),between the treatment group and the control group after treatment (t=1.48,P＞0.05),and between the control group before and after treatment (P＞0.05).Conclusions Mecobalamine can effectively reduce plasma Hcy level in cerebral infarction patients with high plasma Hcy,and alleviate the symptoms of anxiety,depression,nervousness and other emotions.
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In order to deduce the sleep stages from heart rate, we analyze the heart rate variability (HRV) with hidden Markov model (HMM) for the identification of different characters of HRV within different sleep stages. Special technique is used to compensate the individual diversity. The relationship between the sleep stage and the ultra-low frequency components of HRV is also considered. Since the detection of heart rate hardly disturbs the sleep, the proposed method provides a simple approach to evaluating the sleep stage without disturbing the sleep. Our experiments have proved that this method meets the requirements of wide applications, especially the requirement of routine use in monitoring the normal subjects' sleep.
Subject(s)
Adult , Humans , Middle Aged , Electrocardiography , Heart Rate , Markov Chains , Models, Biological , Sleep Stages , PhysiologyABSTRACT
It is estimated that epilepsy, a chronic disorder of the nervous system, affects about 0.5%-2% of the population and about 10%-50% do not respond well to current antiepileptic medications and may not be candidates for surgery. For these patients, the unpredictability of seizure onset is a major cause of disability and mortality. Therefore, anticipation of an imminent seizure would be beneficial to patients because it could provide time for the application of preventive measures to keep the risk of seizure to a minimum. This paper reviews the feasibilities, the progress, existing problems and possible applications in the field of epileptic seizure prediction.
Subject(s)
Humans , Algorithms , Diagnosis, Computer-Assisted , Methods , Electroencephalography , Methods , Epilepsy , Diagnosis , Seizures , Diagnosis , Signal Processing, Computer-AssistedABSTRACT
Objectives To identify genotypes of 31 Sporothrix schenckii (S.schenckii) strains by Southern blotting and to explore the relationship between genotypes and geographic distributions and clinical manifestations.Methods Total DNA was extracted by cetyltriethyl ammonium bromide (CTAB).The polymorphisms were detected by hybridization of ApaⅠ-digested S.schenckii genomic DNA with a probe amplified from the small-subunit rDNA and adjacent internal transcribed spacer (ITS) regions.The band patterns manifested by Southern blotting were employed to investigate genotypes of 31 strains of S.schenckii collected from five different areas in China.Results Of 31 strains of S.schenckii,15 individual patterns (DNA Type A-O) were recognized.Type A to C accounted for 51.61% of all strains.Conclusion The Southern blotting provides a highly sensitive and reliable means for DNA typing of S.schenckii.It is also found that there is an obvious correlation between DNA patterns and different geographic distribution and clinical manifestations.
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Evoked potentials are widely used in clinical neurophysiology. The conventional analysis methods of evoked potentials are based on the waves in time domain. Analysis based on time-spatial domain will provide more information than simple time domain analysis. The existing temporal-spatial analysis methods, such as microstate, frequency domain analysis and event-related coherence, are introduced in this paper.