ABSTRACT
Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)is one of the most common clinical critical illnesses in ICU.The basic pathological features of this disease are uncontrolled inflammation, destruction of the alveolar-capillary barrier and diffuse alveolar and interstitial edema.In severe cases, patients may develop significant pulmonary fibrosis.Based on the pathological changes, repairing damaged alveolar-capillary membrane and reducing fibrosis seem to be the key to the treatments of ALI/ARDS.Vascular endothelial growth factor(VEGF) is known to be the main regulator of endothelial cell proliferation and differentiation.Previous studies have suggested that VEGF plays an important role in the inflammatory reactions and pathological manifestations of ALI/ARDS, but the results are complex.This review mainly focused on the expression changes of VEGF in ALI/ ARDS and the effects and mechanisms of regulating VEGF signaling.
ABSTRACT
Peritoneal dialysis is the most common form of renal replacement therapy in neonates.Due to its technical simplicity and compliance with neonatal physiological characteristics, peritoneal dialysis, especially acute peritoneal dialysis(APD), has been paid increasing attention in clinical practice in recent years.APD in neonates can be effective in treating critical diseases such as renal failure and metabolic disturbances.Despite the increasingly extensive application of APD, existing clinical practice shows a relatively high rate of complications and mortality in APD neonates.In this article, the application, prognosis and related factors of APD in neonates were reviewed.