ABSTRACT
Lipid metabolism plays an important role in the development of life activities and disease.Lipid metabolism is obviously abnormal in patients with tumor disease.It regulates the abnormal expression of genes and proteins by affecting the signal transduction pathway, thus the outcome is promoting transformation, invasion and metastasis of malignant cells, or playing an opposite role.Characteristics of lipid metabolism are different among patients with different tumors.The writer reviewed the research progress of basic and epidemiological studies on the relationship between lipid metabolism and malignant tumors, aimed to prevent, treat and judge the prognosis of malignant tumors.
ABSTRACT
Objective To investigate the effect of As_2O_3 on normal mouse bone marrow stromal cells(BMSCs).Methods BMSCs and colony-forming unit-granulocyte macrophage (CFU-GM) were cultured in vitro to observe the quantitative changes of colony-forming unit-fibroblast(CFU-F) and CFU-GM after BMSCs were treated with different concentrations of As_2O_3 respectively;the quantitative changes of CFU-GM supported by BMSCs and granulocyte colony stimulating factor(G-CSF) and IL-11 secreted by BMSCs were also observed after the progenitor cells supported by BMSCs were treated with As_2O_3 for 3,5 and 7 d,respectively.Results The productions of CFU-F and CFU-GM supported by BMSCs were decreased obviously when treated with 7 ?mol?L~(-1) As_2O_3,also the levels of G-CSF and IL-11 secreted by BMSC(P