ABSTRACT
Objective This cross sectional study was designed to estimate the intensity and duration of DTP by analyzing serum anti-Bordetella pertussis toxin (PT) IgG antibodies among children in Shanghai. The results may provide scientific evidence for developing vaccination protocol and assessing vaccination effect. Methods Blood samples were obtained from 372 children (0-18 years of age) in Shanghai. The serum level of anti-PT IgG was determined by commercial ELISA kits. Anti-PT IgG level ≥30 IU/mL was defined as positive if no pertussis vaccine was vaccinated in the past year, which indicates recent contact with Bordetella pertussis. Anti-PT IgG level ≥100 IU/mL suggests an acute infection. Results The mean concentration of anti-PT IgG antibody was 16.21 IU/mL in the 372 subjects. Serum anti-PT IgG was positive (≥30 IU/mL) in 42 (11.29％) children. The highest positive rate was found in the age group of ＜3 years old (18.60％), followed by the age group of 10-12 years old (11.43％), and the lowest positive rate in the age group of 3-5 years old (7.46％). The mean level of anti-PT IgG antibody was 21.82 IU/mL in the age group of ＜3 years old, 21.16 IU/mL in the age group of 10-12 years old, and the lowest (9.74 IU/mL) in the age group of 6-9 years old. Conclusions Atypical B. pertussis infection is prevalent among younger children in Shanghai. Booster dose of pertussis vaccine may be useful in reducing the incidence of pertussis in children.
ABSTRACT
Mycoplasma pneumoniae pneumonias are common in children.In recent years,the incidence of refractory mycoplasma pneumonia has been increasing,and some of the severe children have a poor response to macrolide antibiotics.However,the effect of glucoconicoid therapy may have unexpected results.The recognition of severe mycoplasma pneumonia risk factors may contribute to intervent with glucocorticoid early,reduce the occurrence of severe mycoplasma pneumonia,and improve the prognosis.Clinical studies have found that clinical manifestations,imaging findings,laboratory tests and other factors are related to the occurrence of severe mycoplasma pneumonia.In this paper,the risk factors that may be associated with accurrence of severe mycoplasma pneumonias are reviewed.
ABSTRACT
Asthma, a complex polygenetic disease, has individual differences in patient′s response to asthma drugs,which is mainly related to gene polymorphism. These genes include beta 2-adrenaline receptor genes(ADRB2),the glucocorticoid receptor genes(NR3C1) and leukotriene synthase genes(LTC4S and ALOX5),etc. Pharmacogenomics can realize individualized treatment of asthma,reduce the admission rate and the mortality rate,and reduce the cost of treatment. Pharmacogenomics of children asthma is reviewed in this arti-cle,hoping to provide help for the individualized treatment of asthma.