Review of study on peripheral nerve regeneration promoted by traditional Chinese medicines / 中国中药杂志

Peripheral nerve impairment is a common complication in surgery, clinical researchers always do nerve sutrure using microsurgical technique and adjuvant treatment to improve peripheral nerve regeneration. Western medicine used usually adjuvant drugs, such as neurotrophic factors,are limited by their defects in clinical application. Traditional Chinese medicines (TCMs) classifies peripheral nerve impair as flaccidity Zheng and arthromyodynia, and considers that it is the result of stagnant blood block in the meridians and vessels, deficient of Qi and blood and disuse of bones and muscles. So, drugs usually have the function of invigorating vital energy, activating blood circulation and dredging collaterals. Mono-drugs include astragalus, Salvia miltiorrhiza, Astragali Radix, Epimedii Folium and so on. Extracts of TCMs have Ginkgo Folium, Cervi Cornu Pantotrichum, Achyranthis Bidentatae Radix, and so on. To be ready for further study and development, TCMs which can promote the peripheral nerve regeneration were reviewed by the literatures of the latest years.

Preventive and therapeutic effect of buyang huanwu decoction on denervated tibial muscle atrophy of rats / 中国药理学通报

Aim To study the preventive and therapeutic effects of Buyang Huanwu Decoction(BYHWD)on denervated tibial muscle atrophy of rats.Methods After 60 Sprague-Dawley rats were subjected to Common Peroneal nerve crush model of 5 mm injury, they were randomly divided into 6 groups for daily intragastric administration of drugs:BYHWD high-dose, medium-dose, low-dose groups, mecobalamin group(positive control), model group, sham operation group.The drug administration lasted for 18 days.18 days after operation, slice, masson staining and analysis morphology were performed. The wet weight ratio and section area of tibial muscle were also measured.Results Tibial muscle section area of sham operation group was large, morphous was regular, while that of model group significantly diminished, structure was chaotic, and connective tissue hyperplasia was more obvious;Tibial muscle section area of BYHWD group and mecobalamin group was fairly diminished, morphous was fairly regular, and connective tissue hyperplasia was not obvious.Compared with model group, the section area of BYHWD group all increased significantly(P <0.01)in a dose-dependent manner.Compared with mecobalamin group, the cross section area of BYHWD high-dose group was significantly larger(P <0.05).Compared with model group, the wet weight ratio of BYHWD high-dose and medium-dose group all increased significantly(P <0.01 or P <0.05)in a dose-dependent manner.Conclusion BYHWD has a significant effect of prevention and therapy on denervated tibial muscle atrophy of rats.