ABSTRACT
Objective To investigate the changes of mi crovascular endothelial dilatation in stunned myocardium. Methods Thirteen healthy and adult mongrel dogs were randomly organized into two groups, group A (n=6) and group B (n=7). Each dog in group A and B underwent 15 min and 30 min acute ligation at left anterior descending coronary artery (LAD), respectively. Myocardial contrast echocardiography was implemented via intra-femoral vein bolus injection of C 3F 8-exposed sonicated dextrose albumin at different examining time.Peak-intensity (PI) and area under curve (AUC) were derived from time-intensity curve (TIC) after aortic root injection of acetylcholine (ACH) or nitroglycerin (NG),and then PI ratio (PIR) and AUC ratio (AUCR) of pre- to post-ACH or pre- to post- NG were calculated at each of the corresponding examining times. Myocardial endothelium-dependent relaxation (EDR) and non-EDR were analyzed at different examining times. Results ①At baseline (before LAD ligation), PI and AUC in group A and B increased considerably via aortic root injection of ACH and NG. ② After ACH injection,PIR in group A decreased sharply at 5,30 and 60 min, whose P values were less than 0.05 compared with baseline. And all these recovered completely at 120 min reperfusion. However,PIR in group B recovered slowly and reached finally to baseline at 150 min reperfusion. Meanwhile, the variation trends of AUCR in both group A and B were the same as those of PIR. Overall, the dynamic tendencies of PIR and AUCR in these two groups for post-NG at different examining times were much similar to those of post-ACH. ③ The decreased magnitudes of PIR and AUCR in group A and B after ACH injection were bigger than those of NG injection at 5,30 and 60 min reperfusion(P
ABSTRACT
The reliability and reliable indexes of quantitative assessment of coronary flow reserve (CFR) by using time-intensity curve (TIC) via myocardial contrast echocardiography were investigated. The TIC variables were obtained by employing acoustic densitometry (AD) technique before and after acetylcholine (Ach) injection in 12 dogs. Meanwhile, the correlation between these variables and CFR was analyzed. Among the variables derived from TIC, peak intensity (PI), area under the curve (AUC) and descending slope (DS) were increased significantly (P < 0.05) with the increase of coronary blood flow after Ach injection. Conversely, time-to-peak (TP), half-time of descent (HT), and mean-transit-time (MTT) were decreased remarkably (P < 0.0001). The PI and AUC ratios from post- to pre-Ach injection were strongly associated with CFR with the correlation coefficient (r) being 0.8366 and 0.8824, respectively. It is reliable by using the variables derived from TIC with myocardial contrast echocardiography to quantitatively evaluate regional myocardial CFR. The PI and AUC ratios from post- to pre-Ach injection are the reliable indexes for quantitative assessment of CFR.
Subject(s)
Animals , Dogs , Blood Flow Velocity , Physiology , Contrast Media , Coronary Circulation , Physiology , Coronary Vessels , Diagnostic Imaging , Physiology , Echocardiography , Methods , Image Processing, Computer-Assisted , Observer Variation , Regional Blood Flow , Physiology , Reproducibility of Results , Ultrasonography, InterventionalABSTRACT
The reliability and reliable indexes of quantitative assessment of coronary flow reserve (CFR) by using time-intensity curve (TIC) via myocardial contrast echocardiography were investigated. The TIC variables were obtained by employing acoustic densitometry (AD) technique before and after acetylcholine (Ach) injection in 12 dogs. Meanwhile, the correlation between these variables and CFR was analyzed. Among the variables derived from TIC, peak intensity (PI), area under the curve (AUC) and descending slope (DS) were increased significantly (P < 0.05) with the increase of coronary blood flow after Ach injection. Conversely, time-to-peak (TP), half-time of descent (HT), and mean-transit-time (MTT) were decreased remarkably (P < 0.0001). The PI and AUC ratios from post- to pre-Ach injection were strongly associated with CFR with the correlation coefficient (r) being 0.8366 and 0.8824, respectively. It is reliable by using the variables derived from TIC with myocardial contrast echocardiography to quantitatively evaluate regional myocardial CFR. The PI and AUC ratios from post- to pre-Ach injection are the reliable indexes for quantitative assessment of CFR.
Subject(s)
Blood Flow Velocity/physiology , Contrast Media , Coronary Circulation/physiology , Coronary Vessels/physiology , Coronary Vessels/diagnostic imaging , Echocardiography/methods , Image Processing, Computer-Assisted , Observer Variation , Regional Blood Flow/drug effects , Regional Blood Flow/physiology , Reproducibility of Results , Ultrasonography, InterventionalABSTRACT
The reseclability of 45 cases with pancreato-ampullar diseases was evaluated preoperatively with color Doppler flow imaging(CDFI).In 43,the situation was confirmed by surgery and pathology with obvious involvement of the peripancreatic vessels and/or liver metastases as the criteria for nonresectability. 22 patients considered to be not resectable on the basis of CDFl were proved at surgerY.While in 21 patients without sign of obvious involvement of peripancreatic vessels on CDFI,the resectability rate was 85.7%.The overall correlation rate of CDFl was 93%.It is concluded that CDFI plays a definite role in evaluating the resectability of panereato-ampullar disease.The positive signs of vessel involvement are discussed.