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Objective To evaluate of the glucose screening retest for gestational diabetes mellitus (GDM) during pregnancy. Methods A retrospective analysis of 714 pregnant women screened for GDM, between December 1,2001, and December 31,2002, was performed.The first glucose challenge test(GCT) was performed in 16～27 week and retested in 28～38 week.Diagnosis of GDM was based on the criteria of Dong.NDDG criteria was also discussed. Results (1) 1-hour glucose value of 50 g GCT ≥7.8 mmol/L was set as abnormal.The first 50 g GCT abnormal rate was 26.6%(190/714),and the retest abnormal rate was 35.2%(225/639).The mean age of pregnant women in 50 g GCT positive group was significantly higher than that in the negative group( P
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Objective To determine the relationships between serum leptin levels and maternal weights in late pregnancy and cord blood leptin levels to birth weights, C peptide, insulin and insulin like growth factor (IGF II). Methods Fifty normal pregnant women at 37～38 weeks and their newborns were studied, and 29 non pregnant women were set as control. Venous blood was taken from women and from the cord at delivery. Blood leptin and cord blood C peptide, insulin, and IGF II were measured by radio immunoassay. Results The average leptin level in maternal sera was (13.62?3.68)?g/L, significantly higher than that in the control (6.60?3.04)?g/L and that in cord blood (8.05?4.61)?g/L. Maternal leptin levels were significantly correlated with maternal weights and body mass index (BMI. r =0.33, 0.35, P 0.05). Cord blood leptin levels were significantly correlated with birth weights and BMI ( r =0.54, 0.49, P 0.05). Significant difference of the cord leptin levels was not seen between the males and females. The cord blood C peptide was (0.86?0.35) ?g/L, insulin (8.49?4.76) mU/L and IGF Ⅱ(0.218?0.076) ?g/L. Cord leptin levels were correlated with C peptide levels ( r =0.37, P 0.05). Conclusions Maternal leptin levels in late pregnancy were significantly higher than those in normal non pregnant women and positively correlated with maternal weights and BMI. Cord blood leptin levels were positively correlated with birth weights and BMI of the newborns. The leptin levels of cord blood were correlated with those of C peptide but not insulin and IGF II.
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Objective To study the plasma lactic acid and blood gas and their value in the umbilical artery of the newborns. Methods The umbilical artery blood samples of 62 newborns were obtained immediately after delivery and then blood gas analysis and plasma lactic acid values were measured within ten minutes. Results The mean value of umbilical artery plasma lactic acid was:(4.4?1.7)mmol/L,pH:7.22?0.07,Base excess:(-5.4?2.7)mEq/L. The lactic acid value had a significant negative relationship with pH values (r=-0.86,P