ABSTRACT
Objective To investigate the serum sex hormone changes and fertility condition in childbearing age women patients with hyperthyroidism treated by iodine-131 .Methods 50 cases of healthy volunteers were selected .248 childbearing age women pa-tients with hyperthyroidism were divided into the iodine-131 group and the anti-thyroid medication group according to the treatment method .The thyroid function and gonad hormone before treatment and at 6 months after treatment were detected in 3 groups ,and the pregnancy and fetal condition were tracked .Results The change of thyroid stimulation hormone(TSH) level was more sensitive in the iodine-131 treatment group than the anti-thyroid medication group ;luteinizing hormone(LH) ,follicle stimulation hormone (FSH) ,prolactin(PRL) ,testosterone(T) and progesterone(P) before treatment in the two groups were significantly increased com-pared with the control group ,but E2 was decreased ;the changes of sex hormones in the iodine-131 treatment group had differences between before and after treatment ,the changes of T and P in the anti-thyroid medication group were unobvious before and after treatment ;the normal delivery rate in the control group and the iodine-131 therapy group had no statistical difference (χ2 =0 .148 , P=0 .7>0 .05) ,the normal delivery rate in the control group and the anti-thyroid medication group had statistically significant difference(χ2 = 5 .739 ,P=0 .017<0 .05) ,the normal delivery rate in the iodine-131 therapy group and the anti-thyroid medication group had statistically significant difference(χ2 =4 .26 ,P=0 .039<0 .05) .Conclusion The iodine-131 therapy has no influence on the sex hormones and the fertility ability in childbearing age women patients with hyperthyroidism ,and also does not increase the incidence rate of genetic damage .
ABSTRACT
Objective To study the relationship between antibody-rdeased test and the morbidity of hyperbilirubinemia in newborns.Methods According to the laboratory rules,serological tests were practised with neonatal umbilical blood of 1 013 A or B blood-type neonates delivered by O-type blood mothers.The morbidity of hyperbilirubinemia were grouping studied in 7 days after birth tO the neonates according to test results.Results(1)The morbidity of hyperbilirubinemia neonates with positive antibody release test results was much higher than that of control group(P＜0.01).(2)Of the antibody release test positive results,there were significant differences among the three groups in which the degree of red cell agglutination were different (P＜0.01).(3)Of the antibody-released test positive results,there was no significant difference in the morbidity of hyperbihrubinemia between the neonates sensitized by the anti-A+B IgG and those not sensitized by the anti-A+B IgG(P＞0.05).There had significant difference in the morbidity of hyperbilirubinemia between the neonates with free antibody and those without free antibody(P＜0.01).Conclusion The different results of antibody release test play some role in the clinical judgement whether hyperbilirubinemia of newborns will occur.
ABSTRACT
Objective To study the relationship between the antigenic titer of anti-A(B) IgG in pregnant women with blood-type O and the incidence of hyperbilirubinemia in newborns with blood-type A or B.Methods The antigenic titer of anti-A(B) IgG were determined in pregnant women with blood-type O whose blood type were incompatible with their mates'.Serological tests for the umbilical blood were analyzed in the neonates with blood-type A or B.The incidence and the pathogenic time of hyperbilirubinemia in newborns were studied by gravidity and test results.Results (1) There was no significant difference in the antigenic titer of anti-A(B) IgG,test results of umbilical blood and the incidence of hyperbilirubinemia between the first and the second pregnancy (P>0.05).(2) With the antigenic titer of anti-A(B) IgG increased,there was significant difference in the positive rate of antibody releasing test to newborns,positive rate of free antibody and the incidence of hyperbilirubinemia (P<0.01).(3) The incidence of hyperbilirubinemia in neonates whose results of antibody releasing test were positive and the antigenic titer of anti-A(B) IgG≤1∶64 were much higher than control group(P<0.01).(4)There was no significant difference in the incidence of hyperbilirubinemia in 3 days after birth (P>0.05).Conclusion The gravidity is not correlative with the antigenic titer of anti-A(B) IgG and the incidence of hyperbilirubinemia in neonates.The risk of hyperbilirubinemia in neonates increases as the antigenic titer of anti-A(B) IgG in gravida ≥1∶32.The incidence of hyperbilirubinemia in neonates become higher as the antigenic titer of anti-A(B) IgG in their mother increasing,however,it has no influence on the onset time of hyperbilirubinemia in newborns.
ABSTRACT
Objective To discuss the relationship between the titer of immunoglobulin Ab-A(B) in the O- type-blood pregnant women and the morbidity of hyperbilirubinemia which the A(B)-type-blood neonates developing. Methods The Ab-A(B) titer of the pregnant wives whose blood type was O and didn't match their husbands' was determined. Determine the serology with umbilical blood of the A(B)-type-blood neonates was determined, and the morbidity of hyperbilirubinemia which happened to those antibody-released test positive neonates was determined.Results (1)In the 271 A(B)-type-blood cases,when the pregnant woman's Ab-A(B) titer≥32,from low to high,the positive incidence of the antibody-released test and indirect antiglobulin test heightened remarkably(P